Antibacterial amide macrocycles iv

A compound of formula

• in which
• R7 represents a group of formula
• whereby
• R1 is hydrogen or hydroxy,
• * is the linkage site to the carbon atom,
• R2 represents hydrogen, methyl or ethyl,
• R3 represents a group of formula
• whereby
• * is the linkage site to the nitrogen atom,
• A represents a bond or phenyl,
• R4 represents hydrogen, amino or hydroxy,
• R5 represents a group of formula
• wherein
• * is the linkage site to the carbon atom,
• R23 represents hydrogen or a group of formula *—(CH2)n—OH or *—(CH2)o—NH2,
• wherein
• * is the linkage site to the carbon atom,
• n and o independently of one another are a number 1, 2, 3 or 4,
• m is a number 0 or 1,
• R8 and R12 independently of one another represent a group of formula *—CONHR14 or *—CH2CONHR15,
• wherein
• * is the linkage site to the carbon atom,
• R14 and R15 independently of one another represent a group of formula
• wherein
• * is the linkage site to the nitrogen atom,
• R4a represents hydrogen, amino or hydroxy,
• R5a represents hydrogen, methyl or aminoethyl,
• R6a represents hydrogen or aminoethyl,
• or
• R5a and R6a together with the nitrogen atom to which they are bonded form a piperazine ring,
• R8a and R12a independently of one another represent *—(CH2)Z1a—OH, *—(CH2)Z2a—NHR13a, *—CONHR14a or *—CH2CONHR15a,
• wherein
• * is the linkage site to the carbon atom,
• Z1a and Z2a independently of one another are a number 1, 2 or 3,
• R13a represents hydrogen or methyl,
• and
• R4a and R15a independently of one another represent a group of formula
• in which
• * is the linkage site to the nitrogen atom,
• R4c represents hydrogen, amino or hydroxy,
• R5c represents hydrogen, methyl or aminoethyl,
• R6c represents hydrogen or aminoethyl,
• kc is a number 0 or 1,
• and
• lc is a number 1, 2, 3 or 4,
• R9a and R11a independently of one another represent hydrogen or methyl,
• R10a represents amino or hydroxy,
• R16a represents a group of formula
• wherein
• * is the linkage site to the nitrogen atom,
• Rd represents hydrogen, amino or hydroxy,
• R5d represents hydrogen, methyl or aminoethyl,
• R6d represents hydrogen or aminoethyl,
• kd is a number 0 or 1,
• and
• ld is a number 1, 2, 3 or 4,
• ka is a number 0 or 1,
• and
• la, wa, xa and ya independently of one another are a number 1, 2, 3 or 4, R9 and R11 independently of one another represent hydrogen, methyl, *—C(NH2)═NH or a group of formula
• wherein
• * is the linkage site to the nitrogen atom,
• R20 represents hydrogen or *—(CH2)i—NHR22,
• wherein
• R22 represents hydrogen or methyl,
• and
• i is a number 1, 2 or 3,
• R21 represents hydrogen or methyl,
• f is a number 0, 1, 2 or 3,
• g is a number 1, 2 or 3,
• and
• h is a number 1, 2, 3 or 4,
• or
• R8 represents *—(CH2)Z1—OH,
• wherein
• * is the linkage site to the carbon atom,
• Z1 is a number 1, 2 or 3,
• and
• R9 represents a group of formula
• wherein
• * is the linkage site to the nitrogen atom,
• and
• h is a number 1, 2, 3 or 4,
• R10 represents amino or hydroxy,
• R16 and R17 independently of one another represent a group of formula
• wherein
• * is the linkage site to the nitrogen atom,
• R4b represents hydrogen, amino or hydroxy,
• R5b represents hydrogen, methyl or aminoethyl,
• R6b represents hydrogen or aminoethyl,
• or
• R5b and R6b together with the nitrogen atom to which they are bonded form a piperazine ring,
• R8b and R12b independently of one another represent *—(CH2)Z1b—OH, *—(CH2)Z2b—NHR13b, *—CONHR14b or *—CH2CONHR15b,
• wherein
• * is the linkage site to the carbon atom,
• R3b represents hydrogen or methyl,
• and
• Z1b and Z2b independently of one another are a number 1, 2 or 3,
• and
• R14b and R15b independently of one another represent a group of formula
• wherein
• * is the linkage site to the nitrogen atom,
• R4g represents hydrogen, amino or hydroxy,
• R5g represents hydrogen, methyl or aminoethyl,
• R6g represents hydrogen or aminoethyl,
• kg is a number 0 or 1,
• and
• lg is a number 1, 2, 3 or 4,
• R9b and R11b independently of one another represent hydrogen or methyl,
• R10b represents amino or hydroxy,
• kb is a number 0 or 1,
• lb, wb, xb and yb independently of one another are a number 1, 2, 3 or 4,
• R18 and R19 independently of one another represent hydrogen or a group of formula
• wherein
• * is the linkage site to the nitrogen atom,
• R4e represents hydrogen, amino or hydroxy,
• R5e represents hydrogen, methyl or aminoethyl,
• R6e represents hydrogen or aminoethyl,
• or
• R5e and R6e together with the nitrogen atom to which they are bonded form a piperazine ring,
• R8e and R12e independently of one another represent *—(CH2)Z1e—OH or *—(CH2)Z2e—NHR13e,
• wherein
• * is the linkage site to the carbon atom,
• R13e represents hydrogen or methyl,
• and
• Z1e and Z2e independently of one another are a number 1, 2 or 3,
• R9e and R11e independently of one another represent hydrogen or methyl,
• R10c represents amino or hydroxy,
• ke is a number 0 or 1,
• and
• le, we, xe and ye independently of one another are a number 1, 2, 3 or 4,
• whereby R18 and R19 are not simultaneously hydrogen,
• R24 represents a group of formula *—CONHR25,
• wherein
• * is the linkage site to the carbon atom,
• R25 represents a group of formula
• wherein
• * is the point of linkage to the nitrogen atom,
• R4f represents hydrogen, amino or hydroxy,
• R5f represents hydrogen, methyl or aminoethyl,
• R6f represents hydrogen or aminoethyl,
• or
• R5f and R6f together with the nitrogen atom to which they are bonded form a piperazine ring,
• R8f and R12f independently of one another represent *—(CH2)Z1f—OH or *—(CH2)Z2f—NHR13f,
• wherein
• * is the linkage site to the carbon atom,
• R3f represents hydrogen or methyl,
• and
• Z1f and Z2f independently of one another are a number 1, 2 or 3,
• R9f and R11f independently of one another represent hydrogen or methyl,
• R10f represents amino or hydroxy,
• kf is a number 0 or 1,
• and
• lf, wf, xf and yf independently of one another are a number 1, 2, 3 or 4,
• d and e independently of one another are a number 1, 2 or 3,
• k is a number 0 or 1,
• l, w, x and y independently of one another are a number 1, 2, 3 or 4,
• independently of one another may when w, x or y equals 3 carry a hydroxy group,
• or one of its salts, its solvates or the solvates of its salts.