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US 2008/0076183 A1Published application
Polysaccharide-peptide conjugates for use as thrombin substrates
AssigneeDade Behring Marburg GmbH
InventorsDaniela Stoellner, Thilo Henckel
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Abstract
The present invention relates to macromolecular polysaccharide-peptide conjugates which contain a peptide portion which C-terminally contains the amino acid sequence Ala-Gly-Arg, which is cleaved by thrombin.
Claims14
A polysaccharide-peptide conjugate having a molecular weight of more than 10 kDa, wherein the peptide portion comprises the sequence Ala-Gly-Arg-R on its C-terminus and wherein R is a signal group cleavable by thrombin.
A method for the determination of the thrombin generation in a sample, the method comprising
- (a) obtaining a blood or plasma sample of a patient,
- (b) mixing the sample with the polysaccharide-peptide conjugate and a suitable activator, and
- (c) measuring the amount of signal group released over time, wherein the polysaccharide-peptide conjugate has a molecular weight of more than 10 kDa, wherein the peptide portion comprises the sequence Ala-Gly-Arg-R on its C-terminus, and wherein R is a signal group cleavable by thrombin.
Dependencies are inferred from the claim text.