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US 2008/0076167 A1Published application
3-hydroxypropionic acid and other organic compounds
AssigneeCargill, Incorporated
InventorsRavi GOKARN, Olga SELIFONOVA, Holly JESSEN, Steven GORT, Thorsten SELMER, Wolfgang BUCKEL
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Abstract
Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed.
Claims25
A method of making 3-hydroxypropionic acid (3-HP), comprising:
- culturing at least one cell comprising at least one exogenous nucleic acid molecule encoding at least one polypeptide that is capable of producing said 3-HP from phosphoenolpyruvate (PEP), pyruvate, or lactate under conditions such that said 3-HP is produced.
A method for making 3-HP, comprising:
- contacting β-alanine with a peptide having 4-aminobutyrate aminotransferase activity to form malonate semialdehyde;
- and
- contacting the malonate semialdehyde with a peptide having 3-hydroxyisobutyrate dehydrogenase or 3-HP dehydrogenase activity to make 3-HP.
Dependencies are inferred from the claim text.