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US 2008/0076141 A1Published application
Novel murine and human kinases
AssigneeImmunex Corporation
InventorsTimothy Bird, G. Virca, Unja Martin, Dirk Anderson
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Abstract
The invention is directed to purified and isolated novel murine and human kinase polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
Claims16
An isolated nucleic acid molecule selected from the group consisting of:
- (a) the DNA sequence of SEQ ID NOs:1-7;
- (b) an isolated nucleic acid molecule encoding an amino acid sequence comprising the sequence of SEQ ID NOs:8-14;
- (c) an isolated nucleic acid molecule that hybridizes to either strand of a denatured, double-stranded DNA comprising the nucleic acid sequence of (a) or (b) under conditions of moderate stringency in 50% formamide and 6×SSC, at 42° C. with washing conditions of 60° C., 0.5×SSC, 0.1% SDS;
- (d) an isolated nucleic acid molecule derived by in vitro mutagenesis from SEQ ID NOs:1-7;
- (e) an isolated nucleic acid molecule degenerate from SEQ ID NOs:1-7 as a result of the genetic code;
- and
- (f) an isolated nucleic acid molecule that is at least 80% identical to any of (a)-(e).
4 more elements
An isolated kinase polypeptide comprising an amino acid sequence selected from the group consisting of:
- (a) amino acids 1-275, 25-275, 140-226, or 149-175 of SEQ ID NO:8;
- (b) amino acids 1-302, 8-302, 26-302, 34-295, 60-229, 157-183, or 198-229 of SEQ ID NO:9;
- (c) amino acids 1-355, 23-279, 124-221, 134-169, or 183-214 of SEQ ID NO:10;
- (d) amino acids 1-631, 57-309, 129-254, 175-200, or 215-247 of SEQ ID NO:11;
- (e) amino acids 1-311, 14-271, 41-213, 124-161, or 175-206 of SEQ ID NO:12;
- (f) amino acids 1-266, 1-261, 25-258, 101-233, 149-175, or 190-226 of SEQ ID NO:13;
- (g) amino acids 1-1360, 25-306, 25-258, 101-233, 149-175, or 190-226 of SEQ ID NO:14;
- (h) an amino acid sequence that is at least 80% identical to any of the amino acid sequences of (a)-(g) above.
5 more elements
Dependencies are inferred from the claim text.