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US 2008/0076136 A1Published application
Transient receptor potential channel TRPM8 and its use
AssigneesIrm LLC, Novartis AG
InventorsStuart Bevan, Pamposh Ganju, Peter McIntyre, Ardem Patapoutian, Andrea Peier, Chuanzheng Song
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Abstract
This invention provides novel genes and polypeptides of the transient receptor potential channel family, and use of these genes and polypeptides for the treatment of pain and identification of agents useful in the treatment of pain.
Claims33
An isolated TRPM8 nucleic acid molecule comprising a member selected from the group consisting of:
- a) a polynucleotide that encodes a mouse TRPM8 protein comprising amino acid residues 1-1104 of SEQ ID NO:
- 8;
- b) a polynucleotide that encodes a mouse TRPM8 protein comprising amino acid residues 2-1104 of SEQ ID NO:
- 8;
- c) a polynucleotide that encodes a polypeptide that comprises one or more functional domains of a mouse TRPM8 protein;
- d) a polynucleotide that encodes a human TRPM8 protein comprising amino acid residues 1-1268 of SEQ ID NO 11;
- e) a polynucleotide that encodes a human TRPM8 protein comprising amino acid residues 2-1268 of SEQ ID NO 11;
- f) a polynucleotide that encodes a polypeptide that comprises one or more functional domains of a human TRPM8 protein;
- and
- g) a polynucleotide that is complementary to a polynucleotide of a) through f).
7 more elements
An isolated TRPM8 polypeptide comprising a member selected from the group consisting of:
- a) a mouse TRPM8 protein comprising amino acid residues 1-1104 of SEQ ID NO:
- 8;
- b) a mouse TRPM8 protein comprising amino acid residues 2-1104 of SEQ ID NO:
- 8;
- c) one or more functional domains of a mouse TRPM8 protein;
- d) a human TRPM8 protein comprising amino acid residues 1-1268 of SEQ ID NO 11;
- e) a human TRPM8 protein comprising amino acid residues 2-1268 of SEQ ID NO 11;
- and
- f) one or more functional domains of a human TRPM8 protein.
6 more elements
Dependencies are inferred from the claim text.