Human Protein Phosphatase With EF-Hands-1(PPEF-1)-Related Gene Variant Associated With T-Cell Lymphoblastic Lymphoma
AssigneeVisgeneer, Inc.
InventorKen-Shwo Dai
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Abstract
The invention relates to the nucleic acid and polypeptide sequences of one novel human PPEF-1-related gene variant (PPEF-1V). The invention also provides a process for making the polypeptides of the variant. The invention further provides a use of the nucleic acid and polypeptide sequences of the gene variant in diagnosing T-cell lymophoblastic lymphoma.
Claims17
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:4.
An isolated nucleic acid comprising at least 30 consecutive nucleotides and that includes a di-nucleotide of nucleotides 127 to 128 of SEQ ID NO:3.
A method for detecting the presence of a PPEF polypeptide or fragment thereof in a mammal, which comprises the steps of:
- (a) extracting proteins from a mammal;
- (b) contacting said proteins with an antibody that binds to a PPEF antigen comprising a polypeptide having at least 17 contiguous and unique amino acids from SEQ ID NO:4 that are not found in SEQ ID NO:2;
- and
- (c) detecting said antibody-PPEF antigen binding.
Dependencies are inferred from the claim text.