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US 2008/0076115 A1Published application
Compositions and Methods for Detecting Severe Acute Respiratory Syndrome Coronavirus
AssigneeDiagnostic Hybrids, Inc.
InventorsDavid R. Scholl, Joseph D. Jollick, Laura Gillim-Ross, Jill Taylor, David E. Wentworth
Life of this patent
Estimating the term…
Abstract
The invention provides compositions and methods for detecting the presence of SARS-coronavirus, for screening anti-SARS coronavirus agents and vaccines, and for reducing infection with plus-strand RNA viruses such as SARS-coronavirus.
Claims15
1-40. (canceled)
A method for detecting a virus that is not a plus-strand RNA virus in a sample, comprising:
- a) providing:
- i) a sample;
- ii) cells susceptible to said virus that is not a plus-strand RNA virus;
- and
- iii) at least one protease inhibitor;
- b) contacting said cells and said sample in the presence of said protease inhibitor to produce contacted cells, wherein replication of said virus that is not a plus-strand RNA virus in said contacted cells is not reduced relative to replication of said virus that is not a plus-strand RNA virus in cells not contacted with said protease inhibitor, and wherein replication of a plus-strand RNA virus in said cells contacted with said protease inhibitor is reduced relative to replication of said plus-strand RNA virus in cells not contacted with said protease inhibitor.
3 more elements
48-51. (canceled)
A method for inhibition of human coronavirus 229E replication comprising:
- i) providing a composition comprising the protease inhibitor E64D and Captisol;
- and ii) contacting a cell permissive for 229E replication with said composition under conditions suitable for inhibiting 229E replication in said cell.
56-67. (canceled)
Dependencies are inferred from the claim text.