Taste Making Formulation Comprising The Drug In A Dissolution-Retarded Form And/Or Cyclodextrin In A Dissolution-Enhanced Form
AssigneePfizer Inc.
InventorsDwayne Thomas Friesen, David Keith Lyon, Rodney James Ketner, Jennifer H. Chu
Life of this patent
Estimating the term…
Abstract
Improved taste masking of pharmaceutical compositions of unpleasant-tasting drugs and cyclodextrin is achieved by forming a mixture of drug and cyclodextrin wherein the drug's dissolution rate has been retarded, or the the cyclodextrin's dissolution rate has been enhanced, or by both.
Claims22
A pharmaceutical composition comprising a physical mixture of
- (a) an unpleasant-tasting drug in solid form;
- and
- (b) a cyclodextrin in solid form;
- wherein said drug is in a dissolution-retarded form.
A pharmaceutical composition comprising a physical mixture of
- (a) an unpleasant-tasting drug in solid form;
- and
- (b) a cyclodextrin in solid form;
- wherein said cyclodextrin is in a dissolution-enhanced form.
A pharmaceutical composition comprising a physical mixture of
- (a) an unpleasant-tasting drug in solid form;
- and
- (b) a cyclodextrin in solid form;
- wherein said drug is in a dissolution-retarded form and said cyclodextrin is in a dissolution-enhanced form.
The composition of claim I or 3 wherein said dissolution-retarded form of said drug comprises a coating.
Dependencies are inferred from the claim text.