Additives And Methods For Enhancing Active Agent Elution Kinetics
OwnerRalph A. Chappainventor
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Abstract
The present invention relates to methods and additives for increasing active agent elution rates from elution control coatings and elution control coatings including the same. In an embodiment the invention includes an elution control coating comprising a polymeric matrix and at least about 0.1 wt. % of an additive dispersed within the polymeric matrix. The additive can include polyvinylpyrrolidone or a copolymer thereof. An active agent can be dispersed within the polymeric matrix, the active agent having limited solubility in water. Embodiments of the invention also include a method of forming an elution control coating with accelerated release kinetics. Other embodiments are also included herein.
Claims21
A method of forming an elution control coating with accelerated release kinetics comprising:
- disposing a hydrophobic polymer, an additive comprising polyvinylpyrrolidone, and an active agent having limited solubility in water, on a substrate to form the elution control coating, the elution control coating having a solids concentration of at least about 0.1 wt. % of polyvinylpyrrolidone.
An elution control coating comprising:
- a polymeric matrix;
- at least about 0.1 wt. % of an additive dispersed within the polymeric matrix, the additive comprising polyvinylpyrrolidone or a copolymer thereof;
- and
- an active agent dispersed within the polymeric matrix, the active agent having limited solubility in water.
A method of increasing the elution rate of an active agent from a coating comprising:
- combining a matrix forming polymer, an active agent having limited solubility in water, and a solvent together to form a coating solution;
- adding polyvinylpyrrolidone to the coating solution in an amount sufficient for the coating solution to have a solids concentration of at least about 0.1 wt. % of polyvinylpyrrolidone, and
- disposing the coating solution on a substrate.
A method of forming an elution control coating comprising:
- depositing a polymeric matrix onto a substrate;
- depositing an active agent onto the substrate, the active agent having limited solubility in water;
- and
- depositing polyvinylpyrrolidone onto the substrate in an amount sufficient for the elution control coating to comprise at least about 0.1 wt. % (solids) of polyvinylpyrrolidone.
Dependencies are inferred from the claim text.