Coacervate Microparticles Useful For The Sustained Release Administration Of Therapeutic Agents
AssigneeThe United States of America as represented by the Secretary, Department of Health and Human Services, NIH
InventorPhillip Heller
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Abstract
The present invention relates to novel microparticles formed using a coacervation process, methods of forming the microparticles, and methods of using the microparticles for the sustained release administration of therapeutic agents.
Claims22
A composition comprising microparticles having a matrix structure, wherein the matrix structure comprises the reaction product of at least one cationic polymer, at least one anionic polymer, and a binding component, and wherein the binding component is distributed throughout the matrix structure of the microparticle.
A composition comprising microparticles having a matrix structure, wherein the matrix structure comprises the reaction product of at least one cationic polymer having a binding component covalently attached thereto and at least one anionic polymer, wherein the binding component is distributed throughout the matrix structure of the microparticle.
A composition comprising microparticles having a matrix structure, wherein the matrix structure comprises the reaction product of at least one cationic polymer and at least one anionic polymer having a binding component attached thereto, wherein the binding component is distributed throughout the matrix structure of the microparticle.
A composition comprising microparticles having a matrix structure, wherein the matrix structure comprises the reaction product of at least one cationic polymer having a binding component covalently attached thereto and at least one anionic polymer having a binding component covalently attached thereto, wherein the binding component attached to cationic polymer and the binding component attached to the anionic component are the same or different.
A method of forming microparticles having a matrix like structure and comprising a binding component comprising the steps of:
- (a) forming microparticles by coacervation of at least one cationic polymer and at least one anionic polymer in the presence of a binding component;
- (b) stabilizing the microparticles by exposing the microparticles to a cross-linking agent under conditions to suitable to cross link the microparticles.
A method of administering a sustained release formulation of a therapeutic agent to a subject comprising administering to a subject a composition comprising microparticles having a matrix structure, wherein the matrix structure comprises the reaction product of at least one cationic polymer, at least one anionic polymer, and a binding component, and wherein the binding component is distributed throughout the matrix structure of the microparticle, wherein the therapeutic agent is bound to the binding component.
Dependencies are inferred from the claim text.