Rage Fusion Proteins And Method Of Use
AssigneeTransTech Pharma, Inc.
InventorsAdnan Mjalli, Ye Tian, Jeffrey Webster, Robert Rothlein
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Abstract
Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
Claims78
A fusion protein comprising a RAGE polypeptide directly linked to a polypeptide comprising a CH2 domain of an immunoglobulin or a portion of a CH2 domain of an immunoglobulin.
An isolated nucleic acid sequence encoding a fusion protein comprising a RAGE polypeptide directly linked a polypeptide comprising a CH2 domain of an immunoglobulin or a portion of a CH2 domain of an immunoglobulin.
An expression vector that encodes for a fusion protein comprising a RAGE polypeptide directly linked to a polypeptide comprising a CH2 domain of an immunoglobulin or a portion of a CH2 domain of an immunoglobulin.
A composition comprising a therapeutically effective amount of a RAGE fusion protein in a pharmaceutical carrier, wherein the RAGE fusion protein comprises a RAGE polypeptide directly linked to a polypeptide comprising a CH2 domain of an immunoglobulin or a portion of a CH2 domain of an immunoglobulin.
A method of making a RAGE fusion protein comprising the step of covalently linking a RAGE polypeptide to a polypeptide comprising a CH2 domain of an immunoglobulin or a portion of a CH2 domain of an immunoglobulin.
A method of treating a RAGE-mediated disorder in a subject comprising administering to a subject a RAGE fusion protein comprising a RAGE polypeptide directly linked a polypeptide comprising a CH2 domain of an immunoglobulin or a portion of a CH2 domain of an immunoglobulin.
Dependencies are inferred from the claim text.