Materials and methods to reduce low density lipoprotein cholesterol
AssigneeUniversity of South Florida
InventorsShyam Mohapatra, Arun Kumar
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Abstract
The present invention pertains to nanoparticles, comprising a metal and/or polymer core, with 7-alpha hydroxylase, or an enzymatically active fragment thereof, nicotinamide adenine dinucleotide (NADH) and antibodies, or antibody fragments, specific for low density lipoprotein (LDL), attached to the core. The invention also concerns methods for reducing LDL cholesterol in a human or animal subject by administering nanoparticles of the invention. In a preferred embodiment, both circulating LDL and plasma cholesterol levels are reduced in the subject.
Claims22
A nanoparticle comprising a core comprising a metal and/or a polymer;
- and a low-density lipoprotein (LDL) binding agent, 7-alpha hydroxylase or an enzymatically active fragment thereof, and nicotinamide adenine dinucleotide (NADH) attached to the core.
A composition comprising nanoparticles and a pharmaceutically acceptable carrier, wherein the nanoparticles comprise a core comprising a metal and/or a polymer;
- and a low-density lipoprotein (LDL) binding agent, 7-alpha hydroxylase or an enzymatically active fragment thereof, and nicotinamide adenine dinucleotide (NADH) attached to the core.
A method for reducing low-density lipoprotein, comprising administering an effective amount of nanoparticles to the circulatory system of a subject, wherein the nanoparticles comprising a core comprising a metal and/or a polymer;
- and a low-density lipoprotein (LDL) binding agent, 7-alpha hydroxylase or an enzymatically active fragment thereof, and nicotinamide adenine dinucleotide (NADH) attached to the core.
A method for making a nanoparticle, comprising providing a nanoparticle core comprising a metal and/or polymer;
- and adsorbing a low-density lipoprotein (LDL) binding agent, 7-alpha hydroxylase or an enzymatically active fragment thereof, and nicotinamide adenine dinucleotide (NADH) to the core.
Dependencies are inferred from the claim text.