Use of placental alkaline phosphatase to promote skin cell proliferation

Abstract

Methods for promoting survival and stimulating proliferation of cells in the epidermis and dermis of undamaged mammalian skin are disclosed. The methods comprise the step of administering to an area of the skin a composition comprising a therapeutically effective amount of human placental alkaline phosphatase, or an active derivative. The composition can be administered topically or by injection. Embodiments of the invention also provide regimens for restoring or maintaining the strength and thickness of aging skin, comprising periodically administering a composition by topical application. Other embodiments of the invention further provide methods for promoting survival and stimulating proliferation of cells in the epidermis and dermis of transplanted skin. A composition for topical application is also provided by some embodiments of the invention.

Dependencies are inferred from the claim text.