Virus clearance of neoplastic cells from mixed cellular compositions
AssigneeOncolytics Biotech Inc.
InventorsDonald Morris, Bradley Thompson, Matthew Coffey
Life of this patent
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Abstract
The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different purposes, for example, to purge hematopoietic stem cells prior to transplantation. Also provided are compositions prepared according to this method, and kits comprising a combination of viruses which are useful in this invention.
Claims23
1-25. (canceled)
A method of selectively removing neoplastic cells from a mixed cellular composition, wherein the composition is located outside of a living organism, the method comprising the steps of:
- (a) selecting a mixed cellular composition comprising ras-activated neoplastic cells;
- (b) contacting the mixed cellular composition with a replication-competent oncolytic virus under conditions that result in substantial killing of the ras-actived neoplastic cells, wherein the replication-competent oncolytic virus is not a herpes simplex virus;
- and
- (c) collecting the virus-treated cellular composition.
Dependencies are inferred from the claim text.