Biocompatible scaffolds and adipose-derived stem cells
AssigneeArtecel Sciences, Inc.
InventorsJeffrey Gimble, David Kaplan, Joshua Mauney
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Abstract
The present invention relates to compositions of biocompatible materials and adult stem cells. The present invention also provides methods of alleviating or treating bone defects or soft tissue defects using the compositions.
Claims39
A composition comprising a silk scaffold and an adult stem cell, wherein said adult stem cell is an adipose-derived stem cell (ASC).
A method of making a composition for treating a tissue defect in a mammal, said method comprising seeding a silk scaffold with an adult stem cell to produce a seeded scaffold, wherein said adult stem cell is an adipose-derived stem cell (ASC).
A method of alleviating or treating a bone defect in a mammal, said method comprising administering to said mammal having a bone defect a therapeutically effective amount of a composition comprising a silk scaffold and an adult stem cell, wherein said adult stem cell is an adipose-derived stem cell (ASC) and wherein said composition is exposed to osteogenic stimulants, thereby alleviating or treating said bone defect in said mammal.
A method of alleviating or treating a soft tissue defect in a mammal, said method comprising administering to said mammal having a soft tissue defect a composition comprising a silk scaffold and an adult stem cell, wherein said adult stem cell is an adipose-derived stem cell (ASC) and wherein said composition is been exposed to adipogenic stimulants, thereby alleviating or treating said soft tissue defect in said mammal.
Dependencies are inferred from the claim text.