Methods and formulations for optimal local delivery of cell therapy via minimally invasive procedures
OwnerJesus Casas, Adam Blakstvedt +3inventors
InventorsJesus Casas, Adam Blakstvedt, Molly Schiltgen, Kent Wika, Gyongike Molnar
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Abstract
The present invention relates to methods, kits, and compositions for safe and efficient delivery of a bioagent to a targeted area of an organ. The method comprises preparing a suspension comprising the bioagent, a contrast agent, and a vehicle, wherein said suspension has an osmolarity from about 270 mOsm to about 440 mOsm; and dispensing at least a portion of said suspension into the targeted area. The invention further provides a kit for delivering a bioagent into a targeted area of an organ comprising: a delivery device; a contrast agent; and a vehicle.
Claims65
A method of delivering a composition comprising a bioagent to a targeted area of an organ comprising:
- a) determining an effective total volume for injection of the composition, wherein said determination of the total volume for injection is based on the compliance of tissue in the targeted area;
- b) preparing the composition comprising the bioagent, a contrast agent, and a vehicle, in about the total volume determined in step (a), wherein said composition has a final osmolarity from about 250 mOsm to about 440 mOsm;
- c) administering at least a portion of the composition prepared in step (b) in volumes that optimizes a retention of the bioagent in the targeted area while minimizing systemic distribution;
- and wherein said method provides an administrator with intra-operative feedback.
A method of delivering a bioagent to a targeted area of an organ comprising:
- a) preparing a suspension comprising the bioagent, a contrast agent, a vehicle, wherein said suspension has a final osmolarity from about 250 mOsm to about 440 mOsm, wherein the total volume of the suspension injected into a targeted area is directly proportional to an interstitial capacity, and is determined by an equation:
- tVol=LVim×ISc, wherein tVol is a total volume for injection, LVim is a LV Infarcted mass(g), and ISc is Interstitial capacity (ml/g);
- b) providing the operator with intra-operative feedback;
- and
- c) dispensing at least a portion of said suspension into the targeted area.
A kit for delivering a bioagent into a targeted area of an organ comprising:
- a delivery device;
- a bioagent;
- a contrast agent;
- a vehicle;
- and
- a set of instructions.
Dependencies are inferred from the claim text.