Back to results
US 2007/0249702 A1Published application
Calcilytic compounds
OwnerEric G. Del Mar, Robert M. Barmore +8inventors
InventorsEric G. Del Mar, Robert M. Barmore, Derek Sheehan, Bradford C. Van Wagenen, James F. Callahan, Richard M. Keenan, Nikesh R. Kotecha, Maria Amparo Lago, Linda Sue Southall, Mervyn Thompson
Life of this patent
Estimating the term…
Abstract
The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.
Claims43
1-31. (canceled)
A compound having the chemical formula:
- wherein R1 is selected from the group consisting of:
- alk and cycloalk;
- R2 is selected from the group consisting of:
- C1-C4 alk, cycloalk, alkoxy, H, OH, ═O, C(O)OH, C(O)O—(C1-C4 alk), C(O)NH—(C1-C4 alk), C(O)N(C1-C4 alk)2 SH, S—(C1-C4 alk), NH2, NH—(C1-C4 alk), and N(C1-C4 alk)2;
- R3 and R4 are each independently C1-C4 alk or together cyclopropyl;
- R5 is aryl;
- R6, if present, is selected from the group consisting of:
- hydrogen, C1-C4 alkyl and C1-C4 alkenyl, wherein R6 is not present if R2 is ═O;
- Y1 is selected from the group consisting of:
- covalent bond, alkylene, and alkenylene;
- Y2 is alkylene;
- Y3 is alkylene;
- Z is selected from the group consisting of:
- covalent bond, O, S, NH, N—(C1-C4 alk), alkylene, alkenylene, and alkynylene, provided that if Z is either O, S, NH, or N—(C1-C4 alk), then Y1 is not a covalent bond;
- further provided that Y1 and Z may together be a covalent bond;
- and
- pharmaceutically acceptable salts and complexes thereof.
14 more elements
Dependencies are inferred from the claim text.