Preventive/Therapeutic Drug for Arteriosclerosis
AssigneeTakeda Pharmaceutical Company Limited
InventorsHiromitsu Fuse, Sachio Shibata, Hideaki Tojo
Life of this patent
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Abstract
The present invention provides preventive/therapeutic agents for arteriosclerosis, diabetes mellitus, etc., which comprise glucosylceramide or (and) lactosylceramide synthase inhibitors, expression inhibitors for glucosylceramide or (and) lactosylceramide synthase genes, methods and kits for screening the preventive/therapeutic agents, and so on.
Claims47
1-58. (canceled)
A method of preventing/treating arteriosclerosis, which comprises inhibiting the activity of a glucosylceramide synthase and/or a lactosylceramide synthase.
A method of preventing/treating arteriosclerosis, which comprises administering to a mammal an effective dose of a glucosylceramide synthase inhibitor and/or a lactosylceramide inhibitor.
A method of preventing/treating arteriosclerosis, which comprises inhibiting the expression of a glucosylceramide synthase gene and/or a lactosylceramide synthase gene.
A method of preventing/treating arteriosclerosis, which comprises administering to a mammal an effective dose of an expression inhibitor of glucosylceramide synthase gene and/or lactosylceramide synthase gene.
An antisense polynucleotide, which comprises the entire or part of base sequence complementary or substantially complementary to a base sequence of a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence represented by SEQ ID NO:
- 1 or SEQ ID NO:
- 3, or a partial peptide thereof.
A medicament, which comprises an antisense polynucleotide comprising the entire or part of base sequence complementary or substantially complementary to a base sequence of a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence represented by SEQ ID NO:
- 1 and/or SEQ ID NO:
- 3, or a partial peptide thereof.
A siRNA or shRNA for a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence represented by SEQ ID NO:
- 1 or SEQ ID NO:
- 3, or a partial peptide thereof.
A medicament, which comprises a siRNA or shRNA for a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence represented by SEQ ID NO:
- 1 and/or SEQ ID NO:
- 3, or a partial peptide thereof.
A medicament for preventing/treating arteriosclerosis, which comprises an antibody to a glucosylceramide synthase and/or an antibody to a lactosylceramide synthase.
A diagnostic agent for arteriosclerosis, which comprises an antibody to a glucosylceramide synthase and/or an antibody to a lactosylceramide synthase.
A method for diagnosis of arteriosclerosis, which comprises using an antibody to a glucosylceramide synthase and/or an antibody to a lactosylceramide synthase.
A diagnostic agent for arteriosclerosis, which comprises a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence represented by SEQ ID NO:
- 1, or a partial peptide thereof, and/or a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 3, or a partial peptide thereof.
A method for diagnosis of arteriosclerosis, which comprises using a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence represented by SEQ ID NO:
- 1, or a partial peptide thereof, and/or a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 3, or a partial peptide thereof.
A method for diagnosis of arteriosclerosis, which comprises assaying the level of a glucosylceramide and/or a lactosylceramide in plasma of a mammal.
A method of screening an agent for preventing/treating arteriosclerosis, which comprises using a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof, and/or a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 3, its partial peptide, or a salt thereof.
A kit for screening an agent for preventing/treating arteriosclerosis, which comprises a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof and/or a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 3, its partial peptide, or a salt thereof.
A method of screening an agent for preventing/treating arteriosclerosis, which comprises using a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence represented by SEQ ID NO:
- 1, or a partial peptide thereof, and/or a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 3, or a partial peptide thereof.
A method of screening an agent for preventing/treating arteriosclerosis, which comprises using a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 11, or a partial peptide thereof.
A kit for screening an agent for preventing/treating arteriosclerosis, which comprises a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence represented by SEQ ID NO:
- 1, or a partial peptide thereof, and/or a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 3, or a partial peptide thereof.
A method of screening an agent for preventing/treating arteriosclerosis, which comprises assaying the activity or level of a protein comprising the same or substantially the same amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof, and/or a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 3, its partial peptide, or a salt thereof.
A method of screening an agent for preventing/treating arteriosclerosis, which comprises assaying the level of a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, or a partial peptide thereof, and/or a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 3, or a partial peptide thereof.
Dependencies are inferred from the claim text.