Osteogenic Implant Matrices and Endosseous Tooth Implants with Improved Osteointegration Properties
AssigneeImmundiagnostik AG
InventorFranz Armbruster
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Abstract
Implant articles with improved osseointegrating properties, osteogenic implant materials, and process of inducing differentiation of mesenchymal stem cells, proliferation of osteoblast and attachment of cells to implant surface, comprising the step of impregnating the surface with a solution containing osteoactive bone sialoprotein, recombinant human bone sialoprotein, recombinant His-Myc-Ek-BSP or substantive fragments thereof that have not been in contact with serum containing complement factor H or any other BSP processing material.
Claims10
Implant material treated with bone sialoprotein or substantive fragments thereof that have not been in contact with serum or cannot bind complement factor H, respectively.
Process of improving the osteointegration properties of implant articles, comprising the step of impregnating the surface with a solution containing bone sialoprotein, recombinant human bone sialoprotein, recombinant His-Myc-Ek-BSP or substantive fragments thereof that have not been in contact with serum containing complement factor H.
Process of inducing differentiation of mesenchymal stem cells, proliferation of osteoblast and attachment of cells to an implant material, comprising the step of impregnating the surface with a solution containing bone sialoprotein, recombinant human bone sialoprotein, recombinant His-Myc-Ek-BSP or substantive fragments thereof that have not been in contact with serum containing complement factor H.
Dependencies are inferred from the claim text.