Rearranged squamous cell carcinoma antigen genes II
OwnerEva Rojerinventor
Life of this patent
Estimating the term…
Abstract
The present invention relates to a SCCA1/SCCA2 fusion protein; plasmid containing the same; antibodies of said fusion protein; methods for detecting said protein; methods for diagnosing the presence or absence of SCC by determining the presence of SCCA1/SCCA2 fusion protein.
Claims44
A fusion transcript consisting of a homologue cross-over between two different genes with more than 80% sequence homology in certain regions, in particular regions of cross-over.
A full length fusion transcript protein between SCCA1 and SCCA2 having switched reactive site loops compared to basic promoter.
A substantially full length fusion transcript protein between SCCA1 and SCCA2 having switched reactive site loops compared to basic promoter.
A DNA sequence sequence coding for a fusion SCCA1/SCCA2 protein.
A DNA sequence comprising the nucleotide sequence of exon 2-7 of SCCA1 fused to the nucleotide sequence of exon 8 of SCCA2.
A plasmid comprising the nucleotide sequence corresponding to one or more of exons 2-7 of SCCA1 gene fused to exon 8 of SCCA2 gene.
A plasmid comprising the nucleotide sequence corresponding to exons 2-7 of SCCA1 fused to the nucleotide sequence of exon 8 of SCCA2.
A plasmid comprising the nucleotide sequence corresponding to one or more of exons 2-7 of SCCA2 gene fused to exon 8 of SCCA1 gene.
A plasmid comprising the nucleotide sequence corresponding to exons 2-7 of SCCA2r gene fused to exon 8 of SCCA1 gene.
A protein expression system for production of SCCA1/SCCA2 fusion protein.
A method for detecting the gene rearrangement forming the SCCA1/SCCA2 fusion protein using a cDNA cloning and sequencing analysis of tumor DNA.
A method for detecting the gene rearrangement forming the SCCA2/SCCA1 fusion protein using a cDNA cloning and sequencing analysis of tumor DNA.
A method for detecting the gene rearrangement forming the SCCA1/SCCA2 fusion protein using a Southern blot-technology applied on tumor DNA.
A method for detecting the gene rearrangement forming the SCCA2/SCCA1 fusion protein using a Southern blot-technology applied on tumor DNA.
A method for detecting the gene rearrangement forming the SCCA1/SCCA2 fusion protein using a PCR-analysis technology.
A method for detecting the gene rearrangement forming the SCCA2/SCCA1 fusion protein using a PCR-analysis technology.
A method for detecting the gene rearrangement forming the SCCA1/SCCA2 fusion protein using an amino acid sequencing technology.
A method for detecting the gene rearrangement forming the SCCA2/SCCA1 fusion protein using an amino acid sequencing technology.
A method for detection the SCCA1/A2 fusion protein using Western blotting.
A method for detection the SCCA2/A1 fusion protein using Western blotting.
A monoclonal antibody specific for SCCA1/SCCA2 fusion protein.
A monoclonal antibody specific for SCCA2/SCCA2 fusion protein.
A polyclonal antibody reactive with SCCA1/SCCA2 fusion protein.
A monoclonal antibody specific for SCCA2/SCCA1 fusion protein.
An immunoassay using a monoclonal antibody or polyclonal antibody specific
- for SCCA1/SCCA2 fusion protein for detecting the presence and concentration of SCCA1/SCCA2 fusion protein.
An immunoassay using a monoclonal antibody or polyclonal antibody specific for SCCA2/SCCA1 fusion protein for detecting the presence and concentration of SCCA2/SCCA1 fusion protein.
A method for diagnosing the presence or absence of a squamous cell carcinoma by detecting the SCCA1/SCCA2 fusion protein in a human sample.
A method for diagnosing the presence or absence of a squamous cell carcinoma by detecting the SCCA2/SCCA1 fusion protein in a human sample.
A kit comprising a SCCA1/SCCA2 fusion protein antibody to be used in the determination of the presence or absence of squamous cell carcinoma (SCC).
A kit comprising a SCCA2/SCCA1 fusion protein antibody to be used in the determination of the presence or absence of squamous cell carcinoma (SCC).
Dependencies are inferred from the claim text.