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US 2007/0207167 A1Published application
Immunologically enhanced recombinant vaccines
OwnerCarl Merril, Biswajit Biswas +1inventors
InventorsCarl Merril, Biswajit Biswas, Michael McKinstry
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Abstract
The present invention is directed to recombinant vaccines, based on a phage vector system, which enhance immunological response and allow rapid construction and deployment of vaccines.
Claims12
An infectious, recombinant phage that expresses (a) one or more immunogenic enhancer molecules, and (b) one or more peptides derived from a pathogen of interest which have an epitope that will induce immunological response in a mammalian host cell.
A method for preparing an infectious, recombinant phage, comprising:
- inserting one or more genes encoding for immunogenic enhancer(s) into the phage genome, such that the phage will express the immunogenic enhancer(s) on its coat;
- and
- inserting one or more genes coding for pathogenic immunogen(s) of interest under the control of a mammalian promoter, such that expression of said genes occurs in a mammalian host cell.
Dependencies are inferred from the claim text.