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US 2007/0202040 A1Published application
Blood clot-targeted nanoparticles
AssigneeBarnes-Jewish Hospital
InventorsGregory Lanza, Samuel Wickline
Life of this patent
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Abstract
Emulsions comprising nanoparticles formed from high boiling perfluorochemical substances, said particles coated with a lipid/surfactant coating are made target-specific by directly coupling said nanoparticles to a targeting ligand. The nanoparticles may further include biologically active agents, radionuclides, and/or other imaging agents.
Claims13
A composition for performing an imaging and/or delivery function with respect to a blood clot in a subject,
- said composition comprising an emulsion of nanoparticles, wherein said nanoparticles comprise a core consisting of liquid perfluorocarbon which core is coated with lipid/surfactant and which nanoparticles are coupled directly to at least one targeting ligand that is specific for at least one component characterizing blood clots, and
- wherein the perfluorocarbon is selected from the group consisting of perfluorodecalin, perfluorooctane, perfluorodichlorooctane, perfluoro-n-octyl bromide, perfluoroheptane, perfluorodecane, perfluorotripropylamine, perfluortributylamine, and mixtures thereof, and
- wherein said nanoparticles further include at least one chelator for a paramagnetic metal ion as a magnetic resonance imaging (MRI) contrast agent, and/or
- wherein said nanoparticles further include at least one biologically active agent, and/or
- wherein said nanoparticles further contain at least one radionuclide.
2 more elements
Dependencies are inferred from the claim text.