Transgenic non-human mammal
AssigneeTaisho Pharmaceutical Co., Ltd.
InventorsMakoto Yoshimoto, Masaki Wakamatsu, Aiko Ishii
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Abstract
An object of the present invention is to provide a model animal of Parkinson's disease comprising an α-synuclein gene introduced therein. The present invention provides a transgenic non-human mammal or a portion thereof, wherein an α-synuclein gene is introduced and the gene is expressed in neurons, and the number of dopamine-producing neurons in the substantial nigra is significantly decreased as compared with that of a wild-type animal.
Claims15
A transgenic non-human mammal or a portion thereof, wherein an α-synuclein gene is introduced and the gene is expressed in the neurons, and the number of dopamine-producing neurons in the substantia nigra is significantly decreased as compared with that of a wild-type animal.
Dependencies are inferred from the claim text.