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US 2007/0191936 A1Published application
Endovascular graft coatings
OwnerStuart Williams, David Clapperinventors
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OwnerStuart Williams, David Clapperinventors
Estimating the term…
An endovascular graft, e.g., having both an expandable stent portion and a stent cover portion positioned within and/or surrounding the expandable portion, the graft itself and/or a stent cover portion being coated with a bioactive agent adapted to promote initial thrombus formation, preferably followed by long term fibrous tissue ingrowth. The endovascular graft addresses concerns regarding endoleaking by permitting the graft to be deployed and used in a manner that promotes a short term hemostatic effect in the perigraft region. This short term effect can, in turn, be used to promote or permit long term fibrous tissue ingrowth. Particularly where the stent cover portion is prepared from a porous material selected from PET and ePTFE, the bioactive agent can include a thrombogenic agent such as collagen covalently attached in the form of a thin, conformal coating on at least the outer surface of the stent cover. An optimal coating of this type is formed by the activation of photoreactive groups provided by either the cover material itself, by the bioactive agent itself, and/or by a linking agent.
An endovascular graft comprising an expandable stent portion and a stent cover portion, wherein the stent cover portion comprises a porous, fibrous material having both an outer perigraft surface and an inner luminal surface, and is coated on at least the outer surface with a hemostatic bioactive agent covalently attached by the activation of photoreactive groups provided by the stent cover portion, by the bioactive agent itself, and/or by a linking agent, wherein the coating comprises the bioactive agent attached to the fibers of the material without occluding its pores.
2-5. (canceled)
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9-10. (canceled)
A method of preparing an endovascular graft comprising an expandable stent portion and a stent cover portion, comprising the step of coating at least the outer surface of the stent cover portion with a hemostatic bioactive agent that is covalently attached by the activation of photoreactive groups provided by the stent cover portion, by the bioactive agent, and/or by a linking agent.
12-15. (canceled)
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19-20. (canceled)
A method of preventing endoleaking in the course of deploying and using an endovascular graft that comprises an expandable stent portion and a stent cover, the method comprising the step of first coating the stent cover by a method that comprises the step of coating at least the outer surface of the stent cover portion with a hemostatic bioactive agent that is covalently attached by the activation of photoreactive groups provided by the stent cover portion, by the bioactive agent, and/or by a linking agent.
24-25. (canceled)
29-30. (canceled)
A method of preventing endoleaking in the course of deploying and using an endovascular graft, the method comprising the steps of:
34-35. (canceled)
39-40. (canceled)
A method according to claim 39 wherein the bioactive agent used to coat the surface is itself photoderivatized, and is immobilized in an amount between about 0.05 μg/cm2 to about 10 μg/cm2, and wherein the endovascular graft is provided in the form of a collapsed small diameter tube of on the order of two mm or less overall diameter, and can be expanded to form a larger diameter tube in situ of between about six mm and about thirty mm.
Dependencies are inferred from the claim text.