Drug Delivery Stent with Extended In Vivo Drug Release
AssigneeConor Medsystems, Inc.
InventorsTheodore Parker, John Shanley, Frank Litvack
Life of this patent
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Abstract
A method for reducing the level of restenosis following a stent placement medical intervention involves the continuous administration of a dose of an anti-restenotic agent, such as paclitaxel, from the stent to vascular tissue in need of treatment in a controlled and extended drug release profile for a period of at least 60 days in vivo. The in vivo release profile is determined by in vivo animal experiments involving implanting a series of stents in animals, explanting the stents from the animals at selected time points, and extracting remaining drug from the explanted stents.
Claims44
A method of reducing restenosis comprising:
- providing a drug delivery stent having a dosage of paclitaxel for delivery to an artery, the dosage arranged such that substantially all the paclitaxel is releasable from the stent upon implantation of the stent in the artery;
- implanting the stent within an artery of a patient;
- and
- delivering paclitaxel from the stent in vivo over an administration period beginning on the date of implantation and ending between 60 days and 8 months after implantation, wherein after the administration period no paclitaxel remains on the stent.
A method of reducing restenosis comprising:
- providing a drug delivery stent having a dosage of antirestenotic drug for delivery to an artery, the dosage arranged such that substantially all the drug is releasable from the stent upon implantation of the stent in the artery;
- implanting the stent within an artery of a patient;
- and
- delivering the drug from the stent in vivo over an administration period beginning on the date of implantation and ending between 60 days and 8 months after implantation, wherein after the administration period no drug remains on the stent.
A stent for reducing restenosis comprising:
- a drug delivery stent having initial unexpanded diameter for insertion of the stent into a coronary artery and an expanded diameter for implantation within a coronary artery, the stent having a dosage of paclitaxel for delivery to an artery, the dosage arranged such that substantially all the paclitaxel is releasable from the stent upon implantation of the stent in the artery, wherein the dosage of paclitaxel is arranged to be released over an in vivo administration period beginning on the date of implantation and ending between 60 days and 8 months after implantation, and wherein after the administration period no drug remains on the stent.
A method of reducing restenosis comprising:
- providing a drug delivery stent having a dosage of antirestenotic drug for delivery to an artery;
- implanting the stent within an artery of a patient;
- and
- delivering drug from the stent in vivo over an administration period beginning on the date of implantation and ending within 6 months after implantation, wherein not more than 40% of the drug is delivered in the first 30 days and after the administration period no drug remains on the stent.
Dependencies are inferred from the claim text.