Systems and methods for sensing analyte and dispensing therapeutic fluid
AssigneeMedingo Ltd.
InventorsOfer Yodfat, Ruthy Kaidar
Life of this patent
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Abstract
Systems and methods are provided for sensing analyte (e.g., glucose) and/or dispensing therapeutic fluid (e.g., insulin). The systems and methods are based on transporting the therapeutic fluid through a cannula at least a portion of which is permeable to molecule of the analyte. Sensing and detection of the concentration level of the analyte can be carried out by optical sensing, electrochemical sensing, acoustical sensing etc. Sensing and dispensing can be carried out by sensing and dispensing device operating in either closed or semi-closed loop.
Claims40
Apparatus for in vivo detection of an analyte, comprising:
- at least one housing;
- a cannula comprising a proximal portion located within the housing and a distal portion located external to the housing, wherein the distal portion is configured for subcutaneous placement within a mammal's body and at least a portion of said cannula is permeable to molecules of an analyte;
- a sensor configured to detect a concentration level of the analyte within the cannula;
- and
- a pump residing in the housing and adapted to transport a fluid to the cannula.
Apparatus for in vivo detection of an analyte, comprising:
- a cannula comprising a proximal portion located within a housing and a distal portion located external to the housing, wherein the distal portion is configured for subcutaneous placement within a mammal's body and at least a portion of said cannula is permeable to molecules of an analyte;
- and
- a sensing means, which is configured to detect a concentration level of the analyte within the cannula.
Apparatus for in vivo detection of an analyte and delivery of a therapeutic fluid to the mammal's body, comprising:
- a housing comprising at least a sensor, a pump, a processor and a reservoir for the therapeutic fluid;
- and
- a cannula comprising a proximal portion located within the housing and a distal portion located external to the housing, wherein the distal portion is configured for subcutaneous placement within a mammal's body and at least a portion of said first cannula is permeable to molecules of an analyte;
- wherein the sensor is in communication with the processor and is configured to detect a concentration level of the analyte within the proximal portion of the cannula;
- and
- wherein the pump is in fluid communication with the reservoir and in electrical communication with the processor and is configured to deliver the therapeutic fluid to the mammal's body according to the detected concentration level.
A method for in vivo detection of an analyte, comprising:
- providing a cannula at least a portion of which is permeable to molecules of an analyte;
- positioning the cannula at least partially subcutaneously within a mammal's body;
- transporting a fluid to the cannula;
- and
- sensing a concentration level of the analyte within the cannula at about, or subsequent to, establishing an equilibrium between a concentration level of the analyte within the cannula and a concentration level of the analyte outside the cannula.
A method for in vivo detection of an analyte and for delivery of a fluid to a mammal's body comprising
- providing a cannula at least a portion of which is permeable to molecules of the analyte;
- positioning the cannula at least partially subcutaneously within the mammal's body;
- transporting the fluid to the cannula;
- detecting a concentration level of the analyte within the cannula at about, or subsequent to, establishing an equilibrium between concentration level of the analyte within the cannula and concentration level of the analyte outside the cannula;
- and
- delivering the fluid to the mammal's body in an amount based at least in part on the detected concentration level.
Dependencies are inferred from the claim text.