Process for obtaining amines by reduction of amides
AssigneeTaminco
InventorsRaf Loenders, Ivan Vanden Eynde, Piet Vanneste
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Abstract
Disclosed is a process for the preparation of primary, secondary and tertiary amines via a catalytic hydrogenation of unsubstituted, N-substituted, and N,N-disubstituted amides. The amide is led, together with an auxiliary amine, in vaporised form in a hydrogen containing gas flow over the catalyst. The process can be carried out at relatively low pressures, between 2 and 50 bars, using typical hydrogenation catalysts like CuCr-type catalysts. The amine is obtained with high yield and high selectivity. The process can be carried out in a continuous fixed bed reactor.
Claims20
A process for preparing an amine with following formula:
- comprising the reduction of an amide of following formula:
- with H2 in the presence of an auxiliary amine of the following formula:
- wherein said H2, said auxiliary amine and said amide are all led at least substantially completely in a gaseous form, in a gaseous stream, over a hydrogenation catalyst, at a reaction pressure higher than 2 but lower than 50 bars, and wherein:
- R1 is H or a saturated or unsaturated hydrocarbon group containing from 1 to 23 carbon atoms;
- R2 and R3 are independently H or a hydrocarbon group containing from 1 to 8 carbon atoms, and preferably 1 to 4 carbon atoms, and
- R4 is equal to R1 but may show a different degree of unsaturation.
Dependencies are inferred from the claim text.