Process for the synthesis of substituted alpha-aminoindan derivatives
AssigneePpg-Sipsy
InventorsBlandine Bertrand, Sylvie Blanchet, Alain Burgos, Juliette Martin, Florence Perrin, Sonia Roussiasse, Yvon Derrien
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Abstract
A process is for the preparation of optically active substituted alpha-indanyl amide derivatives of formula (I), which include: an asymmetric hydrogenation reaction of an en-amide derivative of formula (III) in presence of hydrogen and an optically active catalyst, in order to obtain an amide derivative of formula (II), a hydrolysis reaction of the amide derivative of formula (II) obtained in the previous step, in order to obtain optically active-substituted alpha-indanyl amide derivatives of formula (I).
Claims32
1-24. (canceled)
A process for the preparation of an optically active substituted alpha-amino indane compound of formula ():
- wherein
- m is an integer selected from 0, 1, 2 and 3,
- R1 is selected from the group consisting of a hydrogen atom;
- an allyl group having from 1 to 20 carbon atoms;
- an aryl group having from 6 to 20 carbon atoms;
- an alkylaryl group having from 6 to 20 carbon atoms;
- an alkaloyl group;
- and an aryloyl group,
- said method comprising:
- a) an asymnetric hydrogenation reaction of an en-amide compound of formula (III)
- wherein m and R1 are as defined above,
- R2 is selected from the group consisting of a hydrogen atom;
- an allyl group having from 1 to 20 carbon atoms;
- an aryl group having from 6 to 20 carbon atoms;
- and an alcylaryl group having from 6 to 20 carbon atoms,
- in presence of hydrogen and of an optically active catalyst,
- to obtain an armide compound of formula (II):
- b) a hydrolysis reaction of the amide compound of formula (II) obtained in step a), thereby obtaining said optically active substituted alpha-amino indane compound of formula (I).
Dependencies are inferred from the claim text.