Novel bicyclic sulfonamide derivatives which are L-CPT1 inhibitors

A compound of formula (I):

• wherein:
• V is N or —C(R7)—;
• W is a single bond or —C(R8R9)—;
• X is O, S, SO, SO2 or N(R10);
• Y is —C(R11R12)—, —C(R11R12)C(R13R14)—, —C(R11R12)C(R13R14)C(R15R16)—, —C(R11R12)C(R13R14)C(R15R16)C(R17R18)— or —C(R11)═C(R12)—;
• R1, R2, R3, R4 and R5 independently from each other are hydrogen, halogen, cyano, hydroxy, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy, lower-alkyl-C(O), lower-alkyl-C(O)—NH, lower-alkyl-C(O)—N(lower-alkyl), lower-alkyl-S(O)2, NH2—S(O)2, N(H,lower-alkyl)-S(O)2 or N(lower-alkyl)2-S(O)2, NH2—C(O), N(H,lower-alkyl)-C(O), N(lower-alkyl)2-C(O), COOH or lower-alkoxy-C(O), wherein lower-alkyl is optionally substituted with hydroxy, NH2, N(H,lower-alkyl) or N(lower-alkyl)2;
• R6 is an aryl or heteroaryl group, which aryl or heteroaryl group is optionally substituted by 1 to 4 substituents selected from the group consisting of halogen, hydroxy, cyano, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy, lower-alkyl-C(O), lower-alkyl-C(O)—NH, lower-alkyl-C(O)—N(lower-alkyl), lower-alkyl-S(O)2, NH2—S(O)2, N(H,lower-alkyl)-S(O)2, N(lower-alkyl)2-S(O)2, NH2—C(O), N(H,lower-alkyl)-C(O), N(lower-alkyl)2-C(O), lower-alkoxy-C(O), COOH, 1H-tetrazol-5-yl, 5-oxo-4H-[1,2,4]oxadiazol-3-yl, 5-oxo-4H-[1,2,4]thiadiazol-3-yl, 5-thioxo-4H-[1,2,4]oxadiazol-3-yl, 2-oxo-3H-[1,2,3,5]oxathiadiazol-4-yl, SO3H, 3-hydroxy-isooxazol-5-yl, 6-oxo-6H-pyran-3-yl, 6-oxo-6H-pyran-2-yl, 2-oxo-2H-pyran-3-yl, 2-oxo-2H-pyran-4-yl and P(O)(OCH2CH3)OH, wherein lower-alkyl is optionally substituted with COOH, hydroxy, NH2, N(H,lower-alkyl) or N(lower-alkyl)2, and wherein fluoro-lower-alkyl is optionally substituted with hydroxy;
• R7 is hydrogen, halogen, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl, fluoro-lower-alkoxy, hydroxy or hydroxy-lower-alkyl;
• R8 and R9 independently from each other are hydrogen or lower-alkyl;
• R10 is hydrogen, lower-alkyl, cycloalkyl, lower-alkyl-C(O), lower-alkyl-S(O)2, lower-alkoxy-C(O), (lower-alkyl)NH—C(O), or (lower-alkyl)2N—C(O);
• R11, R12, R13, R14, R15, R16, R17 and R18 independently from each other are hydrogen, halogen, hydroxy, lower alkyl, lower-alkoxy, fluoro-lower-alkyl, fluoro-lower-alkoxy, hydroxy-lower-alkyl, aryl, COOH, C(O)O-lower-alkyl or cyano;
• and pharmaceutically acceptable salts and esters thereof.