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US 2007/0191595 A1Published application
6-monoacetylmorphine derivatives useful in immunoassay
AssigneeRoche Diagnostics Operations, Inc.
InventorsMitali Ghoshal, Gerald Sigler, Richard Root
Life of this patent
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Abstract
Analogs of 6-monoacetyl morphine (6-MAM) are described. These include analogs derivatized at either the C-3 position, the C-6 position, or the nor position of the molecule. These analogs allow for elaboration with linkers terminated by a functional group such as an activated ester, the functional groups being useful for attaching the molecule to other entities such as proteins, polysaccharides, and reporter groups.
Claims5
A compound having the structure:
- where R is saturated or unsaturated, substituted or unsubstituted, straight or branched chain of 0-10 carbon or hetero atoms, L is a linker group consisting of 0-2 substituted or unsubstituted aromatic rings, X is NH or O, and Y is NH-Z where Z is a carrier or label.
A compound having the structure:
- where R is CH2 or C═O, L is a saturated or unsaturated, substituted or unsubstituted, straight or branched chain comprising 0-10 carbon or hetero atoms, X is NH or O, and Y is an activated ester.
A compound having the structure:
- where R is CH2 or C═O, L is a saturated or unsaturated, substituted or unsubstituted, straight or branched chain comprising 0-10 carbon or hetero atoms, X is NH or O, and Y is NH-Z where Z is a carrier or label.
Dependencies are inferred from the claim text.