Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine
OwnerVirginia L. Smith-Swintoskyinventor
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Abstract
The present invention is a method for the treatment or prevention of migraine comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as herein defined. The present invention is directed to a method for the treatment and/or prevention of migraine, which includes mono-therapy and alternatively, co-therapy with at least anti-migraine agent.
Claims8
A method of treating migraine comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula (I)
- wherein
- R1 and R2 are each independently selected from the group consisting of hydrogen and lower alkyl;
- R4 is selected from the group consisting of hydrogen and lower alkyl;
- a is an integer from 1 to 2;
- is selected from the group consisting of
- wherein b is an integer from 0 to 4;
- and wherein c is an integer from 0 to 2;
- each R5 is independently selected from the group consisting of halogen, lower alkyl and nitro;
- provided that when
- is
- or
- then a is 1;
- or a pharmaceutically acceptable salt thereof.
A method of treating migraine comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting (2S)-(−)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide;
- and pharmaceutically acceptable salts thereof.
A method of treating migraine comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula (II)
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.