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US 2007/0191463 A1Published application
Substituted melatonin derivatives, process for their preparation, and methods of use
AssigneeAbraxis BioScience, LLC
InventorsChunlin Tao, Cheng-Zhi Yu, Neil Desai, Vuong Trieu
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Abstract
The invention provides 2 aryl substituted derivatives of melatonin. The invention further provides pharmaceutical compositions comprising such derivatives, methods for preparing such derivatives, and methods of using such derivatives to induce general anesthesia, sedation, and/or hypnotic or sleep effects in a patient, and to treat conditions affected by melatonin activity in a patient.
Claims37
1-36. (canceled)
A compound of the formula
- wherein
- R1 is hydrogen, halo or nitro,
- R2 is C4-C20 aryl, and
- R3 is C1-C30 alkyl, C2-C22 alkenyl, C4-C20 aryl, OR,4 S4, NR4R5, (CH2)nOR4, (CH2)nSR4, (CH2)nNR4R or (CH2)nCOR5
- wherein
- n is 0-10;
- R4 and R5, which can be the same or different, are hydrogen, C1-C8 alkyl, C1-C6 alkenyl or C4-C10aryl.
4 more elements
A compound of the formula
- wherein
- R1 is hydrogen or halo,
- R2 is C4-C20 aryl, and
- R3 is C1-C30 alkyl, C2-C22 alkenyl, C4-C20 aryl, OR4, SR4, NR4R5, (CH2)nOR4, (CH2)nSR4, (CH2)nNR4R or (CH2),COR5
- wherein
- n is 0-10;
- R4 and R5, which can be the same or different, are hydrogen, C1-C8 alkyl, C1-C6 alkenyl or C4-C10 aryl.
- This listing of claims replaces all prior versions, and listings, of claims in the application.
5 more elements
Dependencies are inferred from the claim text.