Novel process for the preparation of 1-(9h-carbazol-4-yloxy)-3-[[2-(-methoxyphenoxy)-ethyl] amino]-propan-2-ol
OwnerVenkatasubramanian Tarur, Dhananjay Sathe +1inventors
InventorsVenkatasubramanian Tarur, Dhananjay Sathe, Swapnil Kulkarni
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Abstract
The present invention discloses a novel process for preparation of carvedilol by using eco friendly solvents to obtain the said carvedilol in high purity. The said process comprises, reacting 4-hydroxy carbazole of formula (IV) with epichlorhydrin in presence of an organic solvent and a base at temperatures between 10° C.-30° C.; further reacting the resultant 4-(2,3-epoxypropoxy)- carbazole of formula (II) with a salt of 2-(2-methoxyphenoxy)ethylamine of formula (III), preferably hydrochloride salt in presence of a base and a hydroxylic solvent at temperatures between 30° C.-90° C.
Claims8
A process for the preparation of 1-(9 H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]amino]-propan-2-ol, (Carvedilol) comprising:
- (a) reacting 4-hydroxy carbazole of formula (IV) with epichlorhydrin
- in presence of an organic solvent and a base at temperatures between 10° C.-30° C.
- (b) further reacting the resultant 4-(2,3-epoxypropoxy)-carbazole of formula (II) with a salt of 2-(2-methoxyphenoxy)ethylamine of formula (III), preferably hydrochloride salt in presence of a base
- and a hydroxylic solvent
- at temperatures between 30° C.-90° C.
A process for preparation of Carvedilol as substantially described herein with reference to the foregoing examples 1 to 2.
Dependencies are inferred from the claim text.