Ion channel modulators

A method for treating a disease or disease symptom in a subject comprising administering to the subject an effective amount of a compound of formula (I) or pharmaceutical salt thereof:

• wherein,
• Ar1 is cycloalkyl, aryl, heterocyclyl or heteroaryl, each of which may be optionally substituted with one or more substitutents selected from the group consisting of H, halogen, amino, hydroxy, cyano, nitro, carboxylate, alkyl, alkenyl, alkynyl, cycloalkyl, cyclohexyl, alkoxy, mono and di-alkyl amino, phenyl, carboxamide, haloalkyl, haloalkoxy, and alkanoyl;
• R1 is Ar2 or lower alkyl optionally substituted with Ar2;
• Ar2 is independently selected from cycloalkyl, aryl, heterocyclyl or heteroaryl, each of which may be optionally substituted with one or more substitutents selected from the group consisting of H, halogen, amino, hydroxy, cyano, nitro, carboxylate, alkyl, alkenyl, alkynyl, cycloalkyl, cyclohexyl, alkoxy, mono and di-alkyl amino, phenyl, carboxamide, haloalkyl, haloalkoxy, and alkanoyl;
• each R2 is independently selected from CO2R3, COAr3, CONR3R4, Ar3, CH2NR3R4;
• each R3 is independently selected from H, or lower alkyl;
• each R4 is independently selected from H, lower alkyl, C(O)OR5, C(O)NR5R6, S(O)2NR5R6, C(O)R7, S(O)2R7 or (CH2)pAr3;
• each Ar3 is independently cycloalkyl, aryl, heterocyclyl, or heteroaryl, each optionally substituted with one or more substitutents;
• each p is independently 0 or 1;
• each substitutent for Ar3 is independently selected from halogen, CN, NO2, OR5, SR5, S(O)2OR5, NR5R6, cycloalkyl, C1-C2 perfluoroalkyl, C1-C2 perfluoroalkoxy, 1,2-methylenedioxy, C(O)OR5, C(O)NR5R6, OC(O)NR5R6, NR5C(O)NR5R6, C(NR5)NR5R6, NR5C(NR6)NR5R6, S(O)2NR5R6, R7, C(O)R7, NR6C(O)R7, S(O)R7, or S(O)2R7;
• each R5 is independently selected from hydrogen or lower alkyl optionally substituted with one or more substitutent independently selected from halogen, OH, C1-C4 alkoxy, NH2, C1-C4 alkylamino, C1-C4 dialkylamino or C3-C6 cycloalkyl;
• each R6 is independently selected from hydrogen, (CH2)qAr4, or lower alkyl optionally substituted with one or more substitutent independently selected from halogen, OH, C1-C4 alkoxy, NH2, C1-C4 alkylamino, C1-C4 dialkylamino or C3-C6 cycloalkyl;
• each R7 is independently selected from (CH2)qAr4 or lower alkyl optionally substituted with one or more substitutent independently selected from halogen, OH, C1-C4 alkoxy, NH2, C1-C4 alkylamino, C1-C4 dialkylamino or C3-C6 cycloalkyl;
• each Ar4 is independently selected from C3-C6 cycloalkyl, aryl or heteroaryl, each optionally substituted with one to three substitutents independently selected from halogen, OH, C1-C4 alkoxy, NH2, C1-C4 alkylamino, C1-C4 dialkylamino or 1,2-methylenedioxy;
• and
• each q is independently 0 or 1.