US 2007/0191427 A1 · Use of n-piperidine derivatives for the treatment of neurodegenerative pathologies

Abstract

The present invention relates to chemical compounds, to pharmaceutical and veterinary compositions, and to the use of such compositions for the treatment or prevention of neurodegenerative pathologies and syndromes such as Parkinson's disease, Alzheimer's disease, lesions due to ischaemia and reperfusion, traumatic brain lesions, neuropathy due to HIV, Down's syndrome, diabetic polyneuropathy, muscular dystrophy, multiple sclerosis, Huntington's disease, prion disease, late dyskinesia, tauopathy and demyelinating pathologies, and other life-threatening pathologies such as cardiac/renal/pulmonary/hepatic/intestinal ischaemia-reperfusion, hypertension, diabetes, cancer, shock, toxicity due to drugs and radiation (radiotherapy and radiation protection), inflammatory conditions, atherosclerosis, aging, hyperlipidaemia, hypercholesterolaemia, epilepsy, and rheumatoid arthritis, all of which are known to be associated with an excess production of reactive free radicals. More particularly, the present invention relates to compositions containing antioxidant cyclic (bis)-hydroxylamines derived from N-piperidine as pharmaceutical compositions for the prevention and treatment of pathologies in man and in animals.

Claims10

Dependent claims

Use of a compound of formula:

in which:
R6 is oxyl, hydrogen or hydroxyl, R1, R2, R3 and R4 are selected independently of one another from:
hydrogen
alkyl having from 1 to 12 carbon atoms,
alkenyl having from 2 to 12 carbon atoms,
alkynyl with from 2 to 12 carbon atoms, or
R1 and R2 together are tetramethylene or pentamethylene;
R5 is hydrogen,
alkyl having from 1 to 12 carbon atoms,
cycloalkyl having from 3 to 8 carbon atoms,
alkenyl with from 2 to 12 carbon atoms,
alkynyl having from 2 to 12 carbon atoms, or
in which:
R1, R2, R3 and R4 are as defined above,
R7 is the same as or different from R6 and is selected from hydrogen, oxyl or hydroxyl, and
n is a whole number from 1 to 30,
for the preparation of a pharmaceutical composition for veterinary or human use or of a medicament for the therapeutic or prophylactic treatment of neurodegenerative diseases.

14 more elements

Dependencies are inferred from the claim text.

Use of n-piperidine derivatives for the treatment of neurodegenerative pathologies

Life of this patent

Use of n-piperidine derivatives for the treatment of neurodegenerative pathologies

Life of this patent

Abstract

Claims10