Macrocyclic anilinopyrimidines with substituted sulphoximine as selective inhibitors of cell cycle kinases

Compounds of the general formula I,

• in which
• B is a prop-1,3-ylene, but-1,4-ylene, pent-1,5-ylene or hex-1,6-ylene group which may be substituted one or more times, identically or differently, by
• (i) hydroxy, —NR11R12, cyano, halogen, —CF3, C1-C6-alkoxy, —NR13—C(O)—C1-C3-alkyl, —NR13—SO2—C1-C3-alkyl, —OCF3 and/or
• (ii) one or more C1-C6-alkyl radicals which are optionally substituted one or more times, identically or differently, by hydroxy, —NR11R12, cyano, halogen, —CF3, C1-C6-alkoxy, —NR13—C(O)—C1-C3-alkyl, —NR13—SO2—C1-C3-alkyl or —OCF3,
• R1 is
• (i) a C1-C6-alkyl radical which is optionally substituted one or more times, identically or differently, by hydroxy, —NR11R12, cyano, halogen, C1-C6-alkoxy, —F3 and/or —OCF3, or
• (ii) a C3-C7-cycloalkyl ring which is optionally substituted one or more times, identically or differently, by hydroxy, —NR11R12, cyano, halogen, —CF3, C1-C6-alkoxy, —OCF3 and/or C1-C6-alkyl, or
• (iii) a C6-aryl ring which is optionally substituted one or more times, identically or differently, by hydroxy, —NR11R12, cyano, halogen, —CF3, C1-C6-alkoxy, —OCF3 and/or C1-C6-alkyl, or
• (iv) a heteroaryl ring which is optionally substituted one or more times, identically or differently, by hydroxy, —NR11R12, cyano, halogen, —CF3, C1-C6-alkoxy, —OCF3 and/or C1-C6-alkyl and has 5 or 6 ring atoms,
• R2 is R5, —SO2—R6, —C(O)O—R6, —C(O)—R6, —C(O)—NR11R12, —C(S)—NR11R12, —Si(R7R8R9), —R10—Si(R7R8R9) or —SO2—R10—Si(R7R8R9),
• R3 is
• (i) hydrogen, hydroxy, halogen, cyano, —CF3, C1-C6-alkoxy —OCF3 or —NR11R12, or
• (ii) a C1-C6-alkyl radical which is optionally substituted one or more times, identically or differently, by halogen, hydroxy, C1-C6-alkoxy or the group —NR11R12, or
• (iii) a C1-C6-alkoxy group which is optionally substituted one or more times, identically and/or differently, by halogen, hydroxy, C1-C6-alkoxy or the group —NR11R12, or
• (iv) a C3-C7-cycloalkyl ring which is optionally substituted one or more times, identically or differently, by halogen, hydroxy, C1-C6-alkoxy, the group —NR11R12 and/or C1-C6-alkyl,
• R4 is
• (i) halogen, cyano, nitro, —NR11R12, —CF3, C1-C6-alkoxy or —OCF3 or
• (ii) a C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl radical which is optionally substituted one or more times, identically or differently, by hydroxy, —NR11R12, cyano, halogen, C1-C6-alkoxy, —CF3 and/or —OCF3, or
• (iii) a C6-aryl ring which is optionally substituted one or more times, identically or differently, by hydroxy, —NR11R12, cyano, halogen, —CF3, C1-C6-alkoxy, —OCF3 and/or C1-C6-alkyl, or
• (iv) a heteroaryl ring which is optionally substituted one or more times, identically or differently, by hydroxy, —NR11R12, cyano, halogen, —CF3, C1-C6-alkoxy, —OCF3 and/or C1-C6-alkyl and has 5 or 6 ring atoms,
• X is —S—, —S(O), —NH— or —O—,
• Y is —NR13—, —S—, —S(O)—, or —O—,
• where
• R5 may be a
• (i) C1-C6-alkyl radical or
• (ii) C3-C6-alkenyl radical or
• (iii) C3-C6-alkynyl radical or
• (iv) C6-aryl ring or
• (v) heteroaryl ring having 5 or 6 ring atoms,
• each of which may optionally be substituted one or more times, identically or differently, by hydroxy, —NR11R12, cyano, halogen, —CF3, C1-C6-alkoxy and/or —OCF3,
• R6 may be a
• (i) C1-C6-alkyl radical or
• (ii) C2-C6-alkenyl radical or
• (iii) C2-C6-alkynyl radical or
• (iv) C6-aryl ring or
• (v) heteroaryl ring having 5 or 6 ring atoms,
• each of which may optionally be substituted one or more times, identically or differently, by hydroxy, —NR11R12, cyano, halogen, —CF3, C1-C6-alkoxy and/or —OCF3,
• R7, R8
• and R9 may be independently of one another
• (i) a C1-C6-alkyl radical, and/or
• (ii) a C6-aryl ring,
• R10 is a C1-C3-alkylene group, and
• R11 and R12 may be independently of one another
• (i) hydrogen and/or
• (ii) a C1-C6-alkyl radical, a C3-C7-cycloalkyl radical, a C2-C6-alkenyl radical, and/or
• (iii) a C6-aryl ring and/or
• (iv) a heteroaryl ring having 5 or 6 ring atoms, where (ii), (iii) and (iv) may optionally be substituted one or more times, identically or differently, by hydroxy, —NR13R14, cyano, halogen, —CF3, C1-C6-alkoxy and/or —OCF3, or
• R11 and R12 together with the nitrogen atom form a heterocyclyl ring which has 3 to 7 ring atoms and may optionally be substituted one or more times, identically or differently, by hydroxy, —NR13R14, cyano, halogen, —CF3, C1-C6-alkoxy and/or —OCF3 and may comprise a further heteroatom, and
• R13 and R14 are independently of one another hydrogen or a C1-C6-alkyl radical which is optionally substituted one or more times, identically or differently, by hydroxy, —NH2, cyano, halogen, —CF3, C1-C6-alkoxy and/or —OCF3,
• and the salts, diastereomers and enantiomers thereof.