Biaryl derivatives

A compound of the formula (I):

• wherein:
• R1 is
• (A) a linear or branched alkoxy group, a cycloalkoxy group or a linear or branched lower alkyl group, or
• (B) a formula (II):
• wherein:
• R3 and R4 each independently is a hydrogen atom, a linear or branched lower alkyl group or a cycloalkyl group or R3, R4 and nitrogen atom in the formula (II) together form a four- to seven-membered nitrogen-containing aliphatic heterocyclic group;
• said heterocyclic group may have one oxygen atom as a constituting atom of the ring;
• R2 is a phenyl group or a five- to six-membered unsaturated or partially unsaturated heterocyclic group having 1 to 3 hetero atom(s) in a ring selected from the group consisting of nitrogen atom, sulfur atom and oxygen atom, which may have one to three substitutent(s) in a ring selected from the group consisting of halogen atom, a lower alkyl group, cyano group, nitro group, an alkoxy group, a lower alkylsulfonyl group, oxo group and hydroxyl group;
• Q1 is carbon atom or nitrogen atom;
• Q2 is carbon atom which may be substituted with an oxo group;
• the formula (III):
• (III)
• is a single bond or a double bond;
• A is selected from the group consisting of the substitutent group α, wherein the substitutent group α is selected from;
• wherein:
• R5 is hydrogen atom, a lower alkyl group, a cyano group, an alkoxy group or a trialkylsilyl group, wherein the lower alkyl group may be substituted with an alkoxy group;
• and
• with the proviso that the compound of the formula (I) does not include the compound wherein A is a group of the formula (IV):
• when the formula (V):
• is a group of the formula (V-1):
• and when R2 is an unsubstituted phenyl group;
• and with the further proviso that the compound of the formula (I) does not include the compound wherein A is a group of the formula (IV-1):
• when the formula (V) is a group of the formula (V-2):
• or
• and when R2 is an unsubstituted phenyl group;
• and with the further proviso that the compound of the formula (I) does not include the compound wherein A is a group represented by any of the formula (IV-3):
• when the formula (V) is the formula (V-3):
• and when R2 is an unsubstituted phenyl group;
• or a pharmaceutically acceptable salt thereof.

A compound of the formula (I):

• wherein:
• R1 is
• (1) a linear or branched alkoxy group, a cycloalkoxy group or a a linear or branched lower alkyl group, or
• (2) the formula (II):
• wherein:
• R3 and R4 each independently is a linear or branched lower alkyl group or a cycloalkyl group or R3, R4 and nitrogen atom in the formula (II) together form a four- to seven-membered nitrogen-containing aliphatic heterocyclic group, wherein the heterocyclic group may have one oxygen atom as a constituting atom of the ring;
• R2 is a phenyl group or a five- to six-membered unsaturated or partially unsaturated heterocyclic group having 1 to 3 hetero atom(s) in a ring selected from the group consisting of nitrogen atom, sulfur atom and oxygen atom, which may have one to three substitutent(s) in a ring selected from the group consisting of halogen atom, a lower alkyl group, cyano group, nitro group, an alkoxy group, a lower alkylsulfonyl group, oxo group and hydroxyl group;
• Q1 is carbon atom or nitrogen atom;
• Q2 is carbon atom which may be substituted with an oxo group;
• the formula (III):
• (III)
• is a single bond or a double bond;
• A is a group of the formula (IV-4):
• wherein:
• R5 is a hydrogen atom, a lower alkyl group, a cyano group, an alkoxy group or a trialkylsilyl group;
• wherein the lower alkyl group may be substituted with an alkoxy group;
• and
• with the proviso that the compound of the formula (I) does not include the compound of the formula (I-1):
• or a pharmaceutically acceptable salt thereof.

A compound which is selected from the group consisting of:

• isopropyl 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylate,
• 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylic acid pyrrolidineamide,
• 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylic acid diethylamide,
• 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylic acid piperidineamide,
• isopropyl 4-[1-(2-chlorophenyl)-5-methyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylate, 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylic acid isopropylmethylamide,
• 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylic acid tert-butylamide,
• isopropyl 4-[1-phenyl-5-methyl-1H-[1,2,3]triazole-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylate,
• isopropyl 4-[1-(2-chloropyridin-3-yl)-5-methyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylate,
• isopropyl 4-[1-(2-fluoropyridin-5-yl)-5-methyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylate,
• propyl 4-[1-(2-chloropyridin-3-yl)-5-methyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylate,
• ethyl 4-[1-(2-chloropyridin-3-yl)-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylate,
• 2-methylpropyl 4-[1-(2-chloropyridin-3-yl)-5-methyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylate,
• isopropyl 4-[1-(pyridin-3-yl)-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylate,
• isopropyl 4-[5-cyano-1-phenyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-carboxylate,
• {4-[1-(2-chloropyridin-3-yl)-5-methyl-1H-[1,2,3]triazole-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylic acid pyrrolidineamide,
• 4-[1-(2-fluoro-pyridin-3-yl)-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylic acid isopropylamide,
• 4-[1-(2-chloro-pyridin-3-yl)-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylic acid isopropylmethylamide,
• 4-[1-(2-chloropyridin-3-yl)-5-methyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylic acid piperidineamide,
• 4-[1-(2-chloropyridin-3-yl)-5-methyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylic acid methyl-tert-butylamide,
• 4-[1-(2-chloropyridin-3-yl)-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylic acid tert-butylamide,
• 1-{4-[1-(2-chloropyridin-3-yl)-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridin-1-yl}-3-methyl-1-butanone, isopropyl 4-[1-(2-fluoropyridin-3-yl)-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylate,
• isopropyl 4-[1-phenyl-5-propyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetra-hydropyridine-carboxylate,
• or a pharmaceutically acceptable salt thereof.