Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them

A combinatorial chemical library comprising a plurality of members of formula (V)

• wherein
• R and R1, being the same or different, are independently a hydrogen atom or an optionally substituted group selected from R′, —COR′, —COOR′, —CONHR′, —CONR′R″, —NH—C(═NH)NHR′, —C(═NH)NHR′, —SO2R′, —SO2NHR′ or —SO2NR′R″;
• wherein R′ and R″, the same or different, are independently selected from hydrogen or optionally further substituted straight or branched C1-C6 alkyl, aryl, C3-C6 cycloalkyl or aryl C1-C6 alkyl or R′ and R″ taken together form a C4-C6 alkylene chain;
• Ra, Rb, Rc and Rd, the same or different, are selected among hydrogen, optionally further substituted straight or branched C1-C6 alkyl, aryl, aryl C1-C6 alkyl or —CH2OR′ groups, wherein R′ is as above defined or, Ra and Rb and/or Rc and Rd taken together with the carbon atom to which they are bonded, form an optionally substituted C3-C6 cycloalkyl group;
• m and n, each independently, represent 0 or an integer from 1 to 2, provided that m+n is lower than, or equal to, 2 (m+n≦2).

A method for treating a mammal, including humans, suffering from a disease caused by and/or associated with an altered protein kinase activity, by administering to said mammal in need thereof a therapeutically effective amount of a bicyclo-pyrazole compound of formula (I):

• wherein
• R and R1, being the same or different, are independently a hydrogen atom or an optionally substituted group selected from R′, —COR′, —COOR′, —CONHR′, —CONR′R″, —NH—C(═NH)NHR′, —C(═NH)NHR′, —SO2R′, —SO2NHR′ or —SO2NR′R″;
• wherein R′ and R″, the same or different, are independently selected from hydrogen or optionally further substituted straight or branched C1-C6 alkyl, aryl, C3-C6 cycloalkyl or aryl C1-C6 alkyl or R′ and R″ taken together form a C4-C6 alkylene chain;
• Ra, Rb, Rc and Rd, being the same or different, are independently selected among hydrogen, optionally further substituted straight or branched C1-C6 alkyl, aryl, aryl C1-C6 alkyl or —CH2OR′ groups, wherein R′ is as above defined, or Ra and Rb and/or Rc and Rd, taken together with the carbon atom to which they are bonded, form an optionally substituted C3-C6 cycloalkyl group;
• m and n, each independently, represents 0 or an integer from 1 to 2, provided that m+n is lower than, or equal to, 2 (m+n≦2);
• or a pharmaceutically acceptable salt thereof.