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US 2007/0191382 A1Published application
Novel tricyclic dihydropyrazines as potassium channel openers
AssigneeJanssen Pharmaceutica NV
InventorsXuqing Zhang, Zhihua Sui
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Abstract
The present invention is directed to novel tricyclic dihydropyrazine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to potassium channel.
Claims10
The invention is directed to a compound of formula I:
- R1 is selected from the group consisting of hydrogen, halogen, carboxy, C1-4 alkyl, halogenated C1-4alkyl, —C(O)—C1-4 alkyl, —C(O)-(halogenated C1-4alkyl), —C(O)O—C1-4alkyl, —S(O)0-2—C1-4alkyl, cyano and nitro;
- R2 is selected from the group consisting of hydrogen, halogen, carboxy, C1-4 alkyl, halogenated C1-4alkyl, —C(O)—C1-4 alkyl, —C(O)-(halogenated C1-4alkyl), —C(O)O—C1-4alkyl, —S(O)0-2—C1-4alkyl, cyano and nitro;
- n is 1 to 2.
- R3 is hydrogen or C1-4alkyl;
- or a pharmaceutically acceptable salt thereof.
2 more elements
A compound as in claim 3, wherein
- R1 is selected from the group consisting of hydrogen, fluoro,bromo, chloro, cyano;
- R2 is selected from the group consisting of hydrogen, fluoro, chloro, bromo, cyano;
- n is selected from 1 to 2.
- R3 is hydrogen;
- or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.