ABCA1 elevating compounds

A compound having the structure of Formula I:

• wherein:
• R1 and R2 are independently optionally substituted lower alkyl;
• R3 and R4 are hydrogen;
• R5 is hydrogen or optionally substituted lower alkoxy;
• R6 is hydrogen or optionally substituted lower alkyl;
• R7 and R8 are hydrogen;
• R20 is optionally substituted heteroaryl or —SR14 in which R14 is hydrogen, optionally substituted lower alkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl;
• A and D are independently 5 or 6 membered monocyclic heterocyclic, monocyclic heteroaryl, or monocyclic aryl rings;
• and
• X is oxygen, sulfur, —S(O)—, —S(O)2— or —NR16—, in which R16 is hydrogen, optionally substituted lower alkyl, optionally substituted aryl, —C(O)R12, or —S(O)2R13.