Substituted cinnolin-4-ylamines

A compound of the formula:

• or a pharmaceutically acceptable salt thereof, wherein:
• W, Y and Z are independently N or CRz;
• Rz is independently selected at each occurrence from hydrogen, halogen, cyano, amino, C1-C6alkyl, haloC1-C6alkyl, C1-C6alkoxy and haloC1-C6alkoxy;
• R3 is hydrogen, halogen, cyano, amino, C1-C4alkyl or haloC1-C4alkyl;
• Ar1 and Ar2 are independently selected from 5- to 10-membered aromatic carbocycles and heterocycles, each of which is substituted with from 0 to 3 substituents independently selected from halogen, cyano, nitro and groups of the formula LRa;
• L is independently selected at each occurrence from a single covalent bond, O, C(═O), OC(═O), C(═O)O, O—C(═O)O, S(O)m, N(Rx), C(═O)N(Rx), N(Rx)C(═O), N(Rx)S(O)m, S(O)mN(Rx) and N[S(O)mRx]S(O)m;
• wherein m is independently selected at each occurrence from 0, 1 and 2;
• and Rxis independently selected at each occurrence from hydrogen and C1-C8alkyl, or Rx is taken together with Ra to form an optionally substituted 4- to 7-membered heterocyclic ring;
• and
• Ra is independently selected at each occurrence from:
• (i) hydrogen;
• and
• (ii) C1-C8alkyl, C2-C8alkenyl, C2-C8alkynyl, (C3-C8cycloalkyl)C0-C4alkyl, haloC1-C8alkyl, C2-C8alkyl ether, mono- and di-(C1-C8alkyl)amino, (3- to 10-membered heterocycle)C0-C4alkyl and groups that are taken together with Rx to form a 4- to 7-membered heterocyclic ring, each of which is substituted with from 0 to 6 substituents independently selected from (a) hydroxy, halogen, amino, aminocarbonyl, cyano, nitro, oxo and COOH;
• and (b) C1-C8alkyl, C1-C8alkenyl, C1-C8alkynyl, (C3-C8cycloalkyl)C0-C4alkyl, C1-C8alkoxy, C1-C8alkylthio, C2-C8alkyl ether, C1-C8alkanoyl, C3-C8alkanone, C1-C8alkanoyloxy, C1-C8alkoxycarbonyl, hydroxyC1-C8alkyl, haloC1-C8alkyl, cyanoC1-C8alkyl, phenylC0-C8alkyl, mono- and di-(C1-C6alkyl)aminoC1-C8alkyl, C1-C8alkylsulfonyl, mono- or di-(C1-C8alkyl)aminosulfonyl and (5- to 7-membered heterocycle)C0-C2alkyl.