Heterocyclic modulators of ppar

A compound of structural Formula (I):

• Or a salt, ester, or prodrug thereof, wherein:
• A is selected from the group consisting of aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, any of which may be optionally substituted;
• L1 is selected from the group consisting of —X—, —XOX—, —XS(O)0-2X— and —XS(O)0-2XO—, —XOXO—, —XN(R1)X—, —XS(O)2N(R1)X—, —XC(O)N(R1)X—, —X(CF2)1-3X—, —XC(═O)X—, —XC(═O)OX—, —XN(R1)C(═O)X—, —XN(R1)C(═O)N(R2)X—, —XN(R1)SO2N(R2)X—, —XN(R1)C(═O)OX, —XP(═O)(OR1)X—, —XP(═O)(NR1)X—, —XP(═S)(OR1)X—, —XP(═S)(NR1)X—, and —XS(═O)(═NR1)X—;
• R1 and R2 are hydrogen or are independently selected from the group consisting of lower alkyl, lower alkoxy, lower perhaloalkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower alkoxyalkyl, alkylamino, alkylaminoalkyl, alkylcarbonyl, amido, aminoalkyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, lower cycloalkyl, lower cycloalkyl alkyl, lower haloalkyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, and heterocycloalkyl, any of which may be optionally substituted;
• or R1 and R2, together with the atoms to which they are attached, may be joined to form an optionally substituted heterocycloalkyl or optionally substituted cycloalkyl moiety;
• X is a bond, or is selected from lower alkyl and lower alkenyl, either of which may be optionally substituted;
• Q1-Q6 are independently selected from the group consisting of a bond, C, NR3, S, and O;
• R3 is hydrogen or is selected from the group consisting of lower alkyl, lower alkenyl, aryl, arylalkyl, lower cycloalkyl, lower cycloalkyl alkyl, lower haloalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, R15, and R16, any of which may be optionally substituted;
• R15 and R16 are independently selected from —R18 and —YR18;
• or when bonded to two contiguous atoms, together with the atoms to which they are attached, form a fused bicyclic or tricyclic heteroaryl, either of which may be optionally substituted;
• Y is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, —C(O)N(R1)— and —OX—, any of which may be optionally substituted;
• R18 is selected from the group consisting of —XOXOR5, —XOR5, —XC(O)OR5, —XC(O)NR4R4, —XC(O)NR4OR4, —XC(O)OXOR5, —XC(O)XOR5, —XC(O)N(R4)XOR5, —XC(O)N(R4)(R5) and —XC(O)N(R4)XR5;
• or R18 may be further selected from the group consisting of lower cycloalkyl, heterocycloalkyl, aryl and heteroaryl, any of which may be further optionally substituted with —XS(O)0-2R1, —XS(O)0-2XR19, —XN(R1)(R2), —XN(R1)S(O)0-2R1, —XN(R1)C(O)R2, —XC(O)N(R1)(R2), —XN(R1)(R19), —XC(O)N(R1)(R19), —XC(O)R19, —XC(O)OR1, —XN(R1)XR19 and —XOXR;
• R4 and R5 are hydrogen or are independently selected from the group consisting of lower alkyl, lower cycloalkyl, heterocycloalkyl, aryl and heteroaryl, any of which may be optionally substituted;
• or R4 and R5, together with the atom to which they are attached, may be joined to form an optionally substituted heterocycloalkyl or optionally substituted heteroaryl moiety;
• and
• R19 is selected from the group consisting of lower cycloalkyl, heterocycloalkyl, aryl and heteroaryl, any of which may be optionally substituted.