3,4,6-Substituted pyridazines for treating neuropathic pain and associated syndromes

A method of treating a mammalian subject suffering from opiod dependence and/or withdrawal, said method comprising:

• administering to said subject a therapeutically effective amount of a 3,4,6-substituted pyridazine having the following structure:
• where
• R2 is selected from the group consisting of lower alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkyloxy, aryloxy, arylalkyloxy, alkylthio, alkylsulfoxide, alkylsulfone, arylthio, arylsulfoxide, aryl sulfone, arylalkylthio, arylalkylsulfoxide, arylalkylsulfone, monoalkylamino, dialkylamino, monoarylamino, monoalkylmonoarylamino, and alkylamino, where the alkylamino may be linear or branched, or may be a nitrogen-containing heterocycle or a substituted nitrogen-containing heterocycle such as a 1-(2-pyrimidyl)piperazine);
• R3 is selected from aryl, alkylcarbonyl, arylcarbonyl, and
• where R5 and R6 are each independently selected from H, alkyl, or a nitrogen-containing heterocycle (e.g., morpholino, piperazino, 4-alkylpiperazino, and the like), or when taken together with N, form a cycloalkylamino ring;
• R7 is selected from H, alkyl, alkoxyalkyl, and arylalkyl;
• and X is selected from H, halogen, alkyl, substituted alkyl such as trifluoromethyl, alkoxyalkyl, and arylalkyl,
• whereby as a result of said administering, the subject experiences relief of said opiod dependence and/or withdrawal.