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US 2007/0191355 A1Published application
Process for preparing intermediates to 5-HT4 receptor agonist compounds
AssigneeTheravance, Inc.
InventorsDaniel Genov, Junning Lee, Jyanwei Liu
Life of this patent
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Abstract
The invention provides 8-azabicyclo[3.2.1 ]octyl intermediates useful for the preparation of 5-HT4 receptor agonist compounds. The invention also provides processes for the preparation of such useful intermediates.
Claims13
A compound of formula (I):
- wherein:
- R1 is selected from hydrogen, —OH, and —OP1, wherein P1 is a hydroxy-protecting group;
- R2 is ═O or —NRaRb, wherein Ra and Rb are independently hydrogen or P2, wherein P2 is an amino-protecting group;
- A is selected from —OC(O)—, —S(O)2—, and a covalent bond;
- W is selected from —N(R3)C(O)R4, —N(R5)S(O)2R6, and a moiety of formula (a):
- wherein Z is selected from NC(O)R4, NS(O)2R6, S(O)2, NH, and NP2;
- R3, R4, R5, and R6 are independently C1-3alkyl;
- and
- n is 0 or 1;
- or a salt thereof.
7 more elements
Dependencies are inferred from the claim text.