Combinations comprising alpha-2-delta ligands

A combination according to claim 1 or 2, wherein the alpha-2-delta ligand is selected from gabapentin, pregabalin, [(1R,5R,6S)-6-(Aminomethyl)bicyclo[3.2.0]hept-6-yl]acetic acid, 3-(1-Aminomethyl-cyclohexylmethyl)-4H-[1,2,4]oxadiazol-5-one, C-[1-(1H-Tetrazol-5-ylmethyl)-cycloheptyl]-methylamine, (3S,4S)-(1-Aminomethyl-3,4-dimethyl-cyclopentyl)-acetic acid, (1α,3α,5α)(3-amino-methyl-bicyclo[3.2.0]hept-3-yl)-acetic acid, (3S,5R)-3-Aminomethyl-5-methyl-octanoic acid, (3S,5R)-3-amino-5-methyl-heptanoic acid, (3S,5R)-3-amino-5-methyl-nonanoic acid, (3S,5R)-3-Amino-5-methyl-octanoic acid, (2S,4S)-4-(3-chlorophenoxy)proline and (2S,4S)-4-(3-fluorobenzyl)proline, or a pharmaceutically acceptable salt thereof.

Use of an alpha-2-delta ligand in combination with an atypical antipsychotic, or pharmaceutically acceptable salts thereof, in the manufacture of a medicament for the curative, prophylactic or palliative treatment of pain.

A method for the curative, prophylactic or palliative treatment of pain, comprising simultaneous, sequential or separate administration of a therapeutically amount of an alpha-2-delta ligand and an atypical antipsychotic, or pharmaceutically acceptable salts thereof, to a mammal in need of said treatment.

A product containing and alpha-2-delta ligand and an atypical antipsychotic, or pharmaceutically acceptable salts thereof, as a combined preparation for simultaneous, separate or sequential use in the treatment of pain.