Isopropanol water solvate of olanzapine
AssigneeKRKA, Tovarna Zdravil, D.D.
InventorsBerta Kotar-Jordan, Roman Lenarsic, Marija Grcman, Matej Smrkolj, Anton Meden, Igor Simonic, Rok Zupet, Joze Gnidovec, Primoz Benkic
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Abstract
The invention relates to a novel and well defined Oolvate form of olanzapine which contains 2 molecules of water and 1 molecule of isopropanol per 2 molecules of olanzapine, and which can be converted into other, forms of olanzapine, in particular form (I) of olanzapine, as well as processes for preparing form (I) olanzapine.
Claims32
A isopropanol/water mixed solvate of olanzapine which contains 2 molecules of water and 1 molecule-of isopropanol per 2 molecules of olanzapine.
The process according to caim 10, wherein the methylene chloride solvate is methylene chloride hemisolvate of olanzapine.
A process for preparing form I olanzapine, wherein at least one of (a) a precursor for olanzapine form I and (b) olanzapine form I is crystallized or precipitated from a liquid medium which medium is present in a container wherein the surfaces of the container contacting the medium are comprising at least one polymer
The process according to caim 26, wherein the polymer contains fluorine.
Dependencies are inferred from the claim text.