Compounds Which Modulate The CB2 Receptor

A compound of a formula:

• or the pharmaceutically acceptable salts thereof wherein,
• R1 is hydrogen, C1-C6 alkyl optionally substituted with aryl or heteroaryl, C3-C10 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl;
• or,
• R1 is C1-C3 alkyl substituted with Z-R6, wherein Z is O, S, SO2, NH, NMe or CH2 and R6 is optionally substituted aryl or heteroaryl, provided that Y is O or NR3 and n is 2 or 3;
• R2 is hydrogen or C1-C6 alkyl;
• A is a group of the formula —(CH2)n— wherein n is 1, 2 or 3, which is optionally substituted with one or two C1-C6 alkyl groups;
• Y is a methylene group, provided that n is 1, 2 or 3, wherein said methylene group is optionally substituted with a halogen atom or with a C1-C6 alkyl group optionally substituted with one to three halogen atoms;
• or,
• Y is selected from the group consisting of O and NR3, provided that n is 2 or 3, wherein,
• R3 is hydrogen, C1-C6 alkyl optionally substituted by one to 3 halogen atoms, C3-C6 cycloalkyl, phenyl, benzyl, pyridyl, C(O)R4, SO2R4, C(O)NHR4, or C(O)NMeR4, wherein,
• R4 is hydrogen, C1-C6 alkyl optionally substituted by one to 3 halogen atoms, C3-C6 cycloalkyl, phenyl, benzyl or pyridyl;
• or,
• Y is selected from the group consisting of S, SO and SO2, provided that n is 2;
• X is a methylene group optionally mono- or disubstituted with methyl;
• or a carbonyl group;
• Ar1 is a divalent moiety which is either phenylene or a six-membered heteroarylene, which divalent moiety is optionally mono- or disubstituted with moieties selected from the group consisting of C1-C6 alkyl optionally substituted by one to 3 halogen atoms, C3-C10 cycloalkyl and halogen;
• and,
• Ar2 is an aryl or heteroaryl moiety which is optionally substituted with C1-C6 alkyl optionally substituted with 1 to 3 halogen atoms, C1-C6 alkoxy optionally substituted with 1 to 3 halogen atoms, C1-C6 alkylthio, C1-C6 alkoxycarbonyl, C1-C6 alkylaminocarbonyl, C1-C6 dialkylaminocarbonyl, hydroxyl, halogen, cyano or nitro.