Combinations comprising staurosporines
OwnerPeter Atadja, Kapil Bhalla +1inventors
InventorsPeter Atadja, Kapil Bhalla, Pamela Cohen
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method of treating myelodysplastic syndromes, lymphomas and leukemias, and also solid tumors with a pharmaceutical combination of a FLT-3 kinase inhibitor and a histone deacetylase inhibitor (HDAI). It also relates to the use of a pharmaceutical combination of a histone deacetylase inhibitor and a FLT-3 kinase inhibitor for the treatment of the diseases or malignancies mentioned above and the use of such a pharmaceutical composition for the manufacture of a medicament for the treatment of these diseases or malignancies.
Claims23
A method of treating myelodysplastic syndromes, lymphomas and leukemias, and solid tumors in a mammal which comprises treating the mammal in need of such treatment simultaneously, concurrently, separately or sequentially with pharmaceutically effective amounts of (a) a FLT-3 inhibitor, or a pharmaceutically acceptable salt or a prodrug thereof, and (b) a histone deacetylase inhibitor, or a pharmaceutically acceptable salt or a prodrug thereof.
Use of a combination of (a) a FLT-3 inhibitor and (b) a histone deacetylase inhibitor (HDAI) for treating myelodysplastic syndromes, lymphomas and leukemias, and solid tumors.
Use of a combination of (a) a FLT-3 inhibitor and (b) a histone deacetylase inhibitor (HDAI) for the preparation of a medicament for the treatment of myelodysplastic syndromes, lymphomas and leukemias and solid tumors.
A pharmaceutical composition comprising (a) a FLT-3 inhibitor and (b) a histone deacetylase inhibitor for the treatment of myelodysplastic syndromes, lymphomas and leukemias and solid tumors.
Dependencies are inferred from the claim text.