Sterilization of corticosteroids with reduced mass loss

A method of reducing the mass loss of corticosteroid in a sterilization process, comprising filtering a starting corticosteroid solution through a filter to produce a sterilized corticosteroid solution, wherein a mass loss of corticosteroid of less than about 30% is achieved.

A process of making a sterilized solution of corticosteroid, comprising filtering a compounded corticosteroid solution comprising a starting mass of corticosteroid through a filter to produce the sterilized corticosteroid solution, whereby the concentration of the sterilized corticosteroid solution is at least about least about 95%, at least about 96%, at least about 97%, at least about 97.5%, at least about 97.7%, at least about 97.9%, e.g. about 98.2±0.5% or more of the concentration of corticosteroid in the compounded corticosteroid solution.

A method of reducing the loss in concentration of corticosteroid in a sterilization process, comprising filtering a compounded corticosteroid solution comprising a starting mass of corticosteroid through a filter to produce a filtered corticosteroid solution, wherein the filtered corticosteroid solution has a concentration that is at least about 90.0% of the theoretical concentration based on the starting mass of the corticosteroid.

A process of making a sterilized solution of corticosteroid, comprising subjecting a compounded corticosteroid solution to conditions wherein the mass loss between the starting corticosteroid solution and the sterilized corticosteroid solution is less than about 30%, less than about 25%, less than about 20%, less than about 15%, less than about 10%, less than about 5%, less than about 3%, less than about 2% or about 1% or less.

A method of reducing the nass loss of corticosteroid in a sterilization process, comprising subjecting a compounded corticosteroid solution to conditions wherein a mass loss of corticosteroid of less than about 30%, less than about 25%, less than about 20%, less than about 15%, less than about 10%, less than about 5%, less than about 3%, less than about 2% or about 1% or less is achieved.

A process of making a sterilized solution of corticosteroid, comprising subjecting a compounded corticosteroid solution to conditions wherein the concentration of the sterilized corticosteroid solution is at least about 95%, at least about 96%, at least about 97%, at least about 97.5%, at least about 97.7%, at least about 97.9%, e.g. about 98.2±0.5% or more or more of the theoretical concentration based upon the starting mass of corticosteroid.

A method of reducing the loss in concentration of corticosteroid in a sterilization process, comprising subjecting a compounded corticosteroid solution to conditions wherein the concentration of the corticosteroid in the corticosteroid solution has a concentration that is at least about 95%, at least about 96%, at least about 97%, at least about 97.5%, at least about 97.7%, at least about 97.9%, e.g. about 98.2±0.5% or more or more of the theoretical concentration based upon based on the starting mass of the corticosteroid.