Methods for modulating glutamate receptors for treating neuropsychiatric disorders comprising the use of modulators of serum and glucocorticoid inducible kinases
OwnerFlorian Langinventor
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Abstract
Modulation of the activity of serum and glucocorticoid inducible kinases to restore glutamate receptor activity. Also disclosed are methods and compounds useful for the detection and treatment of neuropsychiatric disorders.
Claims7
A method for altering glutamate receptor activity comprising, contacting cells expressing SGK1, SGK2 or SGK3 with a substance that modulates serum and glucocorticoid inducible kinases.
A method for determining the progression, regression or onset of a neuropsychiatric disease by measuring the up-regulated expression of SGK1, SGK2 or SGK3 in tissue samples and specimens.
Use of SGK1 inhibitors selected from the listed compounds having the general formula I or II for the manufacture of a medicament for the treatment of disorders caused by dysregulated glutamate receptors.
Dependencies are inferred from the claim text.